The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids.

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title = "The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids.",
abstract = "The retro-aldol reductive fragmentation of different structural types of 7-hydroxy-9,10-dioxotaxoids was investigated, showing that the reaction is typical of taxanes and requires cerium(III) promotion with NaBH4 in protic medium and alkylboron (aluminium) hydrides in aprotic solvents. The resulting 7,8-seco-taxanes are key intermediates for the synthesis of a novel class of anticancer taxanes endowed with a unique pattern of in vivo biological activity. ({\circledC} Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)",
author = "G Appendino and A Noncovich and P Bettoni and P Dambruoso and Olov Sterner and G Fontana and E Bombardelli",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)",
year = "2003",
doi = "10.1002/ejoc.200300376",
language = "English",
volume = "2003",
pages = "4422--4431",
journal = "Annalen der Pharmacie",
issn = "0075-4617",
publisher = "John Wiley & Sons",
number = "22",