The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids.

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The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids. / Appendino, G; Noncovich, A; Bettoni, P; Dambruoso, P; Sterner, Olov; Fontana, G; Bombardelli, E.

I: European Journal of Organic Chemistry, Vol. 2003, Nr. 22, 2003, s. 4422-4431.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Appendino, G, Noncovich, A, Bettoni, P, Dambruoso, P, Sterner, O, Fontana, G & Bombardelli, E 2003, 'The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids.', European Journal of Organic Chemistry, vol. 2003, nr. 22, s. 4422-4431. https://doi.org/10.1002/ejoc.200300376

APA

Appendino, G., Noncovich, A., Bettoni, P., Dambruoso, P., Sterner, O., Fontana, G., & Bombardelli, E. (2003). The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids. European Journal of Organic Chemistry, 2003(22), 4422-4431. https://doi.org/10.1002/ejoc.200300376

CBE

Appendino G, Noncovich A, Bettoni P, Dambruoso P, Sterner O, Fontana G, Bombardelli E. 2003. The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids. European Journal of Organic Chemistry. 2003(22):4422-4431. https://doi.org/10.1002/ejoc.200300376

MLA

Vancouver

Author

Appendino, G ; Noncovich, A ; Bettoni, P ; Dambruoso, P ; Sterner, Olov ; Fontana, G ; Bombardelli, E. / The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids. I: European Journal of Organic Chemistry. 2003 ; Vol. 2003, Nr. 22. s. 4422-4431.

RIS

TY - JOUR

T1 - The reductive fragmentation of 7-hydroxy-9,10-dioxotaxoids.

AU - Appendino, G

AU - Noncovich, A

AU - Bettoni, P

AU - Dambruoso, P

AU - Sterner, Olov

AU - Fontana, G

AU - Bombardelli, E

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)

PY - 2003

Y1 - 2003

N2 - The retro-aldol reductive fragmentation of different structural types of 7-hydroxy-9,10-dioxotaxoids was investigated, showing that the reaction is typical of taxanes and requires cerium(III) promotion with NaBH4 in protic medium and alkylboron (aluminium) hydrides in aprotic solvents. The resulting 7,8-seco-taxanes are key intermediates for the synthesis of a novel class of anticancer taxanes endowed with a unique pattern of in vivo biological activity. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

AB - The retro-aldol reductive fragmentation of different structural types of 7-hydroxy-9,10-dioxotaxoids was investigated, showing that the reaction is typical of taxanes and requires cerium(III) promotion with NaBH4 in protic medium and alkylboron (aluminium) hydrides in aprotic solvents. The resulting 7,8-seco-taxanes are key intermediates for the synthesis of a novel class of anticancer taxanes endowed with a unique pattern of in vivo biological activity. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)

U2 - 10.1002/ejoc.200300376

DO - 10.1002/ejoc.200300376

M3 - Article

VL - 2003

SP - 4422

EP - 4431

JO - Annalen der Pharmacie

T2 - Annalen der Pharmacie

JF - Annalen der Pharmacie

SN - 0075-4617

IS - 22

ER -