The relationship between left ventricular ejection fraction and infarct size assessed by MRI.

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The relationship between left ventricular ejection fraction and infarct size assessed by MRI. / Ugander, Martin; Ekmehag, Björn; Arheden, Håkan.

I: Scandinavian Cardiovascular Journal, Vol. 42, Nr. 2, 2008, s. 137-145.

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T1 - The relationship between left ventricular ejection fraction and infarct size assessed by MRI.

AU - Ugander, Martin

AU - Ekmehag, Björn

AU - Arheden, Håkan

PY - 2008

Y1 - 2008

N2 - Objectives. We sought to study the relationship between left ventricular ejection fraction (LVEF) and infarct size in patients with ischemic heart disease (IHD) using magnetic resonance imaging (MRI), and to determine a dysfunction index based on the maximum possible LVEF in relation to infarct size. Design. In 149 patients with chronic IHD, LVEF and infarct size were quantified by MRI. Dysfunction index was defined as the maximum possible LVEF minus measured LVEF. Results. The maximum possible LVEF was found to be LVEF=72.2-[1.18*infarct size]. Dysfunction index for the study population was mean 20 (range -6 to 57), 74% of the study population had a dysfunction index >10 and 44% had a dysfunction index >20. Conclusions. The present study suggests that infarct size by MRI can be used to estimate a maximum possible LVEF and a dysfunction index. The distribution of dysfunction index in the population suggests a considerable prevalence of dysfunctional but viable myocardium. Future studies are needed to assess if the dysfunction index can be useful to assess the potential for improvement in LVEF following revascularization.

AB - Objectives. We sought to study the relationship between left ventricular ejection fraction (LVEF) and infarct size in patients with ischemic heart disease (IHD) using magnetic resonance imaging (MRI), and to determine a dysfunction index based on the maximum possible LVEF in relation to infarct size. Design. In 149 patients with chronic IHD, LVEF and infarct size were quantified by MRI. Dysfunction index was defined as the maximum possible LVEF minus measured LVEF. Results. The maximum possible LVEF was found to be LVEF=72.2-[1.18*infarct size]. Dysfunction index for the study population was mean 20 (range -6 to 57), 74% of the study population had a dysfunction index >10 and 44% had a dysfunction index >20. Conclusions. The present study suggests that infarct size by MRI can be used to estimate a maximum possible LVEF and a dysfunction index. The distribution of dysfunction index in the population suggests a considerable prevalence of dysfunctional but viable myocardium. Future studies are needed to assess if the dysfunction index can be useful to assess the potential for improvement in LVEF following revascularization.

U2 - 10.1080/14017430701840317

DO - 10.1080/14017430701840317

M3 - Article

VL - 42

SP - 137

EP - 145

JO - Scandinavian Cardiovascular Journal

JF - Scandinavian Cardiovascular Journal

SN - 1651-2006

IS - 2

ER -