The Role of Complement in Transfusion-Related Acute Lung Injury

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

Transfusion-related acute lung injury (TRALI) is a life-threatening complication of acute respiratory distress occurring within 6 hours of blood transfusion. TRALI is one of the leading causes of transfusion-related fatalities and specific therapies are unavailable. Neutrophils are recognized as the major pathogenic cells, whereas T regulatory cells and dendritic cells appear to be important for protection against TRALI. The pathogenesis, however, is complex and incompletely understood. It is frequently postulated that the complement system plays an important role in the TRALI pathogenesis. In this article, we assess the evidence regarding the involvement of complement in TRALI from both human and animal studies. We hypothesize about the potential connection between the complement system and neutrophils in TRALI. Additionally, we draw parallels between TRALI and other acute pulmonary disorders of acute lung injury and acute respiratory distress syndrome regarding the involvement of complement. We conclude that, even though a role for complement in the TRALI pathogenesis seems plausible, studies investigating the role of complement in TRALI are remarkably limited in number and also present conflicting findings. Different types of TRALI animal models, diverse experimental conditions, and the composition of the gastrointestinal microbiota may perhaps all be factors which contribute to these discrepancies. More systematic studies are warranted to shed light on the contribution of the complement cascade in TRALI. The underlying clinical condition of the patient, which influences the susceptibility to TRALI, as well as the transfusion factor (antibody-mediated vs non–antibody-mediated), will be important to take into consideration when researching the contribution of complement. This should significantly increase our understanding of the role of complement in TRALI and may potentially result in promising new treatment strategies.

Detaljer

Författare
  • Ilse Jongerius
  • Leendert Porcelijn
  • Anna E. van Beek
  • John W. Semple
  • C. Ellen van der Schoot
  • Alexander P.J. Vlaar
  • Rick Kapur
Enheter & grupper
Externa organisationer
  • Academic Medical Center
  • Sanquin Diagnostic Services
  • University of Amsterdam
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Hematologi

Nyckelord

Originalspråkengelska
Sidor (från-till)236-242
TidskriftTransfusion Medicine Reviews
Volym33
Utgåva nummer4
Tidigt onlinedatum2019 okt 18
StatusPublished - 2019
PublikationskategoriForskning
Peer review utfördJa