The Role of Phosphatidylinositol 3-Kinase Signaling Pathways in Pancreatic Cancer

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The Role of Phosphatidylinositol 3-Kinase Signaling Pathways in Pancreatic Cancer. / Sun, Chen; Rosendahl, Ann; Andersson, Roland; Wu, DeQuan; Wang, Xiangdong.

I: Pancreatology, Vol. 11, Nr. 2, 2011, s. 252-260.

Forskningsoutput: TidskriftsbidragÖversiktsartikel

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T1 - The Role of Phosphatidylinositol 3-Kinase Signaling Pathways in Pancreatic Cancer

AU - Sun, Chen

AU - Rosendahl, Ann

AU - Andersson, Roland

AU - Wu, DeQuan

AU - Wang, Xiangdong

PY - 2011

Y1 - 2011

N2 - Background: Pancreatic cancer is a highly malignant cancer and the fourth leading cause of cancer-related death. It is characterized by a rapid disease progression, a highly invasive tumor phenotype, and frequently resistance to chemotherapy. Despite significant advances in diagnosis, staging, and surgical management of the disease during the past decade, prognosis of pancreatic cancer is still dismal. Methods and Results: The phosphatidylinositol 3-kinase (PI3K) signaling pathways regulate cellular growth, metabolism, survival, and motility in pancreatic cancer. Pancreatic cancer is associated with a high degree of genetic alterations that can result in aberrant activation of the PI3K signaling pathway. Elucidating the role of the PI3K signaling pathway in pancreatic cancer may thus be both meaningful and necessary. Conclusion: Improved knowledge of the PI3K signaling pathway in pancreatic cancer would furthermore be helpful in understanding mechanisms of tumor initiation and progression, and in identifying appropriate targeted anticancer treatment in pancreatic cancer. Copyright (C) 2011 S. Karger AG, Basel and IAP

AB - Background: Pancreatic cancer is a highly malignant cancer and the fourth leading cause of cancer-related death. It is characterized by a rapid disease progression, a highly invasive tumor phenotype, and frequently resistance to chemotherapy. Despite significant advances in diagnosis, staging, and surgical management of the disease during the past decade, prognosis of pancreatic cancer is still dismal. Methods and Results: The phosphatidylinositol 3-kinase (PI3K) signaling pathways regulate cellular growth, metabolism, survival, and motility in pancreatic cancer. Pancreatic cancer is associated with a high degree of genetic alterations that can result in aberrant activation of the PI3K signaling pathway. Elucidating the role of the PI3K signaling pathway in pancreatic cancer may thus be both meaningful and necessary. Conclusion: Improved knowledge of the PI3K signaling pathway in pancreatic cancer would furthermore be helpful in understanding mechanisms of tumor initiation and progression, and in identifying appropriate targeted anticancer treatment in pancreatic cancer. Copyright (C) 2011 S. Karger AG, Basel and IAP

KW - PI3K

KW - Signaling pathway

KW - Pancreatic cancer

U2 - 10.1159/000327715

DO - 10.1159/000327715

M3 - Review article

C2 - 21625196

VL - 11

SP - 252

EP - 260

JO - Pancreatology

JF - Pancreatology

SN - 1424-3903

IS - 2

ER -