The serotonergic system in L-DOPA-induced dyskinesia: pre-clinical evidence and clinical perspective

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

During the last decade, the serotonergic system has emerged as a key player in the appearance of L-DOPA-induced dyskinesia in animal models of Parkinson’s disease. Clinical investigations, based on imaging and postmortem analyses, suggest that the serotonin neurons are also involved in the etiology of this complication of long-term L-DOPA treatment in parkinsonian patients. These findings have stimulated efforts to develop new therapies using drugs targeting the malfunctioning serotonin neurons. In this review, we summarize the experimental and clinical data obtained so far and discuss the prospects for further development of this therapeutic strategy.

Detaljer

Författare
Enheter & grupper
Externa organisationer
  • University of Cagliari
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)1195-1202
TidskriftJournal of Neural Transmission
Volym125
Utgivningsnummer8
StatusPublished - 2018 aug
PublikationskategoriForskning
Peer review utfördJa