The use of Methadone in peadiatric cancer PAIN - a retrospective study from a govermental cancer centre in India

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Background: The management of cancer-related pain relies on access to opioids. When regular opioids are not tolerated, or are insufficient, methadone is an affordable and effective analgesic. Aim: The aim of the project was to describe the pattern of use and clinical experience of methadone in pediatric cancer pain at a governmental cancer hospital in Hyderabad, one of the four Indian cancer centers with permission to prescribe methadone. Methods: This was a retrospective study of medical records of all children, under the age of 18, who had been prescribed methadone from September 9, 2017, to November 19, 2019. Data on analgesic effect, prior and concomitant analgesic treatment, opioid side effects, and the handling of methadone were analyzed. Results: A total of 11 children were identified and studied. Methadone was introduced mainly when pain was uncontrolled by regular opioids. Initial daily doses ranged from 1 to 15 mg. The duration of treatment ranged from 7 to 307, with a median of 50 days in the nine patients where treatment exceeded one single dosage. Good analgesic effect was reported in 5/9 children, unchanged from previous analgesic treatment in three patients and without any effect in one child. No severe side effects were reported. Conclusion: Low-dose methadone in the treatment of pediatric cancer pain at a low-resource cancer center was safe and well tolerated by the patients, with long treatment durations. It was safely managed, administered with single to double daily dosages, hence easy for patients and family to handle, and an affordable treatment option.


  • Gayatri Palat
  • Charlotte Algotsson
  • Spandana Rayala
  • Vikranth Haridass
  • Jaya Nethagani
  • Vineela Rapelli
  • Maria Gebre-Medhin
  • Eva Brun
  • Mikael Segerlantz
Enheter & grupper
Externa organisationer
  • Skåne University Hospital
  • Region Skåne
  • Two Worlds Cancer Collaboration
  • MNJ Institute of Oncology, Vancouver

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Medicin och hälsovetenskap
  • Cancer och onkologi


  • methadone, pediatric cancer, Pain management
Sidor (från-till)133-138
TidskriftIndian Journal of Palliative Care
Utgåva nummer1
StatusPublished - 2021 apr 13
Peer review utfördJa