Thermodynamics and kinetics of a Go(o)over-bar proteinlike heteropolymer model with two-state folding characteristics

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

We present results of Monte Carlo computer simulations of a coarse-grained hydrophobic-polar G (o) over bar -like heteropolymer model and discuss thermodynamic properties and kinetics of an exemplified heteropolymer, exhibiting two-state folding behavior. It turns out that general, characteristic folding features of realistic proteins with a single free-energy barrier can also be observed in this simplified model, where the folding transition is primarily driven by the hydrophobic force.

Detaljer

Författare
  • Anna Kallias
  • Michael Bachmann
  • Wolfhard Janke
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biofysik
Originalspråkengelska
Sidor (från-till)055102-7 pp
TidskriftJournal of Chemical Physics
Volym128
Utgivningsnummer5
StatusPublished - 2008
PublikationskategoriForskning
Peer review utfördJa