Three-year outcome of rivastigmine treatment in Alzheimer's disease in a routine clinical setting.
Forskningsoutput: Konferensbidrag › Poster
Objectives: Long-term, placebo-controlled studies of cholinesterase inhibitors (ChEIs) in Alzheimer’s disease (AD) are not permitted for ethical reasons. Therefore, the advancement of knowledge on longitudinal outcomes in different domains warrants well-designed naturalistic studies. The aim of this study was to explore the 3-year effectiveness of rivastigmine treatment. Methods: The Swedish Alzheimer Treatment Study (SATS) is a prospective, open, non-randomised, multicentre study evaluating ChEI therapy in clinical practice. In total, 269 outpatients with a clinical diagnosis of AD received rivastigmine. Patients were assessed using cognitive tests (MMSE, ADAS-cog), global performance (CIBIC) and instrumental ADL (IADL) at baseline, after 2 months and every 6 months for a total period of 3 years. The outcomes were compared with mathematical models of change in untreated AD patients or with historical controls. Results: After 3 years of rivastigmine treatment, the mean decline from baseline in MMSE score was 2.8 points (95% CI, 2.1–3.6); in ADAS-cog score, 5.7 points (3.7–7.7); and in IADL score, 6.2 points (5.2–7.2). This was better than expected compared with mathematical models and historical cohorts of untreated AD patients. Three-year completers (n = 117, 44%) received higher mean ± SD doses of rivastigmine than did drop-outs (7.2 ± 1.9 vs 5.5 ± 2.0 mg/day, p<0.001). Among the completers, 26% exhibited global improvement or were unchanged after 3 years of treatment. Conclusions: Long-term rivastigmine treatment in AD yielded positive cognitive, global and functional outcomes in the routine clinical setting. Completers of the 3-year study tolerated higher doses of rivastigmine better.
|Enheter & grupper|
Ämnesklassifikation (UKÄ) – OBLIGATORISK
|Status||Published - 2013|
|Peer review utförd||Nej|
|Evenemang||11th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD 2013) - Florence, Italien|
Varaktighet: 2013 mar 6 → 2013 mar 10
|Konferens||11th International Conference on Alzheimer’s & Parkinson’s Diseases (AD/PD 2013)|
|Period||2013/03/06 → 2013/03/10|
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