Thylakoids Promote Satiety in Healthy Humans. Metabolic Effects and Mechanisms

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKonferenspaper i proceeding

Abstract

Thylakoids are the photosynthetic membranes of the chloroplasts in green leaves. Thylakoids have been found to promote satiety when added to food, both in animal experimental models and in human. The thylakoids act through inhibition of lipase-colipase catalysed hydrolysis of triacylglycerol, which is the main dietary fat component. The mechanism for inhibition is either a binding of thylakoids to lipase-colipase, which thereby prevents to act as a lipolytic enzyme complex or binding of thylakoids to the triacylglycerol droplet, thereby hindering the access of lipase-colipase to its substrate. Thylakoids consist of proteins and lipids in a membrane structure containing various protein-bound pigments. The thylakoid membranes are fairly resistant to gastrointestinal breakdown, which may be an important property to explain the satiety promoting effect. Satiety is promoted through the release of cholecystokinin, a gastrointestinal hormone that causes an inhibition of gastric emptying and stimulation of satiety mechanism in the brain. The hunger hormone ghrelin is suppressed as well as insulin. In human short-term experiments thylakoids added to food promote satiety signalling. In long-term a reduced body fat mass was observed.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Näringslära
  • Annan klinisk medicin

Nyckelord

Originalspråkengelska
Titel på värdpublikationACS Symposium Series
FörlagThe American Chemical Society (ACS)
Sidor521-531
Volym1093
StatusPublished - 2012
PublikationskategoriForskning
Peer review utfördJa
EvenemangSymposium on Agricultural and Food Derived Natural Products for Preventing and Combating Disease - Boston, MA
Varaktighet: 2010 aug 222010 aug 26

Publikationsserier

Namn
Volym1093
ISSN (tryckt)0097-6156

Konferens

KonferensSymposium on Agricultural and Food Derived Natural Products for Preventing and Combating Disease
Period2010/08/222010/08/26