Tolerability of non-ergot oral and transdermal dopamine agonists in younger and older Parkinson’s disease patients: an European multicentre survey

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

In older patients with Parkinson’s disease (PD), the use of dopamine agonists (DA) has been limited due to uncertainties related to their tolerability in spite of potential gains with the advent of longer acting or transdermal therapies. Comparative real-life data addressing the tolerability of DA therapy across age ranges are currently sparse. This study addressed the tolerability (Shulman criteria, continued intake of DA therapy for at least 6 months) in PD patients across several European centres treated with long-acting and transdermal DA (Rotigotine skin patch, Ropinirole extended release, or Pramipexole prolonged release) as part of routine clinical care in younger and older PD patients. A medical record-based retrospective data capture and clinical interview-based follow-up survey of patients initiating or initiated on DA treatment (short and long acting) in a real-life setting. 425 cases were included [mean age 68.3 years (range 37–90), mean duration of disease 7.5 years (range 0–37), 31.5% older age (≥ 75 years of age)]. Tolerability was above 90% irrespective of age, with no significant differences between younger and older patients. Based on our findings, we suggest that long-acting/transdermal DA are tolerated in non-demented older patients, as well as in younger patients, however, with lower daily dose in older patients.

Detaljer

Författare
  • A. Rizos
  • A. Sauerbier
  • C. Falup-Pecurariu
  • P. Odin
  • A. Antonini
  • P. Martinez-Martin
  • B. Kessel
  • T. Henriksen
  • M. Silverdale
  • G. Durner
  • K. Ray Chaudhuri
  • EUROPAR and the IPMDS Non-Motor PD Study Group
Enheter & grupper
Externa organisationer
  • King's College Hospital
  • King's College London
  • University Hospital of Cologne
  • Transylvania University Brasov
  • University of Padova
  • CIBER Enfermedades Neurodegenerativas (CIBERNED)
  • Bispebjerg Hospital
  • Central Hospital Bremerhaven
  • Salford Royal NHS Foundation Trust
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Allmän medicin
  • Neurologi

Nyckelord

Originalspråkengelska
Sidor (från-till)875-879
Antal sidor5
TidskriftJournal of Neural Transmission
Volym127
Utgåva nummer6
StatusPublished - 2020 maj 5
PublikationskategoriForskning
Peer review utfördJa