Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.

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Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways. / Brandelius, Angelica; Andersson, Morgan; Uller, Lena.

I: Respiratory Medicine, Vol. 108, Nr. 12, 2014, s. 1816-1819.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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T1 - Topical dsRNA challenges may induce overexpression of airway antiviral cytokines in symptomatic allergic disease. A pilot in vivo study in nasal airways.

AU - Brandelius, Angelica

AU - Andersson, Morgan

AU - Uller, Lena

PY - 2014

Y1 - 2014

N2 - Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season.

AB - Airway challenge with dsRNA is of interest since this agent acts on TLR3 and mimics rhinoviral (RV) infection-induced interferons/cytokines. Contrasting frequent employment of dsRNA in epithelial cell cultures there is no information on effects of dsRNA administered to human airways in vivo. Here we explore effects of nasal dsRNA challenges in subjects with seasonal allergic rhinitis inside and outside Swedish birch pollen season.

U2 - 10.1016/j.rmed.2014.10.010

DO - 10.1016/j.rmed.2014.10.010

M3 - Article

VL - 108

SP - 1816

EP - 1819

JO - Respiratory Medicine

T2 - Respiratory Medicine

JF - Respiratory Medicine

SN - 1532-3064

IS - 12

ER -