Towards accurate in vivo spectroscopy of the human prostate

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title = "Towards accurate in vivo spectroscopy of the human prostate",
abstract = "The recent interest in photodynamic therapy of human prostate cancer is accompanied by a need for techniques for in vivo monitoring of optical and physiological characteristics. We propose time-of-flight (TOF) spectroscopy in combination with Monte Carlo evaluation as a reliable optical technique for quantitative assessment of absorption, scattering, hemoglobin content and tissue oxygenation in the human prostate. For the first time, we demonstrate Monte Carlo-based evaluation of in vivo TOF photon migration data. We show that this approach is crucial in order to avoid the large errors associated with the use of time-resolved diffusion theory of light propagation in prostate-like tissues. This progress also allows us to present the first in vivo scattering spectroscopy of human prostate tissue. Furthermore, TOF spectroscopy. in contrast to the more common steady-state approach, is insensitive to bleedings, and has been found highly reliable (100% success rate). (C) 2008 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim",
keywords = "Optical Properties, Time-resolved Spectroscopy, Photon Migration, Tissue Oxygenation, Human Prostate, Hemoglobin, Monte Carlo, White",
author = "Tomas Svensson and Erik Alerstam and Margret Einarsdottir and Katarina Svanberg and Stefan Andersson-Engels",
year = "2008",
doi = "10.1002/jbio.200710025",
language = "English",
volume = "1",
pages = "200--203",
journal = "Journal of Biophotonics",
issn = "1864-063X",
publisher = "John Wiley and Sons",
number = "3",