Towards accurate in vivo spectroscopy of the human prostate

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Towards accurate in vivo spectroscopy of the human prostate. / Svensson, Tomas; Alerstam, Erik; Einarsdottir, Margret; Svanberg, Katarina; Andersson-Engels, Stefan.

I: Journal of Biophotonics, Vol. 1, Nr. 3, 2008, s. 200-203.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Svensson, T, Alerstam, E, Einarsdottir, M, Svanberg, K & Andersson-Engels, S 2008, 'Towards accurate in vivo spectroscopy of the human prostate', Journal of Biophotonics, vol. 1, nr. 3, s. 200-203. https://doi.org/10.1002/jbio.200710025

APA

Svensson, T., Alerstam, E., Einarsdottir, M., Svanberg, K., & Andersson-Engels, S. (2008). Towards accurate in vivo spectroscopy of the human prostate. Journal of Biophotonics, 1(3), 200-203. https://doi.org/10.1002/jbio.200710025

CBE

MLA

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Author

Svensson, Tomas ; Alerstam, Erik ; Einarsdottir, Margret ; Svanberg, Katarina ; Andersson-Engels, Stefan. / Towards accurate in vivo spectroscopy of the human prostate. I: Journal of Biophotonics. 2008 ; Vol. 1, Nr. 3. s. 200-203.

RIS

TY - JOUR

T1 - Towards accurate in vivo spectroscopy of the human prostate

AU - Svensson, Tomas

AU - Alerstam, Erik

AU - Einarsdottir, Margret

AU - Svanberg, Katarina

AU - Andersson-Engels, Stefan

PY - 2008

Y1 - 2008

N2 - The recent interest in photodynamic therapy of human prostate cancer is accompanied by a need for techniques for in vivo monitoring of optical and physiological characteristics. We propose time-of-flight (TOF) spectroscopy in combination with Monte Carlo evaluation as a reliable optical technique for quantitative assessment of absorption, scattering, hemoglobin content and tissue oxygenation in the human prostate. For the first time, we demonstrate Monte Carlo-based evaluation of in vivo TOF photon migration data. We show that this approach is crucial in order to avoid the large errors associated with the use of time-resolved diffusion theory of light propagation in prostate-like tissues. This progress also allows us to present the first in vivo scattering spectroscopy of human prostate tissue. Furthermore, TOF spectroscopy. in contrast to the more common steady-state approach, is insensitive to bleedings, and has been found highly reliable (100% success rate). (C) 2008 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

AB - The recent interest in photodynamic therapy of human prostate cancer is accompanied by a need for techniques for in vivo monitoring of optical and physiological characteristics. We propose time-of-flight (TOF) spectroscopy in combination with Monte Carlo evaluation as a reliable optical technique for quantitative assessment of absorption, scattering, hemoglobin content and tissue oxygenation in the human prostate. For the first time, we demonstrate Monte Carlo-based evaluation of in vivo TOF photon migration data. We show that this approach is crucial in order to avoid the large errors associated with the use of time-resolved diffusion theory of light propagation in prostate-like tissues. This progress also allows us to present the first in vivo scattering spectroscopy of human prostate tissue. Furthermore, TOF spectroscopy. in contrast to the more common steady-state approach, is insensitive to bleedings, and has been found highly reliable (100% success rate). (C) 2008 by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

KW - Optical Properties

KW - Time-resolved Spectroscopy

KW - Photon Migration

KW - Tissue Oxygenation

KW - Human Prostate

KW - Hemoglobin

KW - Monte Carlo

KW - White

U2 - 10.1002/jbio.200710025

DO - 10.1002/jbio.200710025

M3 - Article

VL - 1

SP - 200

EP - 203

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 3

ER -