Towards an optical diagnostic system for otitis media using a combination of otoscopy and spectroscopy

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Towards an optical diagnostic system for otitis media using a combination of otoscopy and spectroscopy. / Hu, Lingna; Li, Wansha; Lin, Huiying; Li, Ying; Zhang, Hao; Svanberg, Katarina; Svanberg, Sune.

I: Journal of Biophotonics, Vol. 12, Nr. 6, e201800305, 2019.

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T1 - Towards an optical diagnostic system for otitis media using a combination of otoscopy and spectroscopy

AU - Hu, Lingna

AU - Li, Wansha

AU - Lin, Huiying

AU - Li, Ying

AU - Zhang, Hao

AU - Svanberg, Katarina

AU - Svanberg, Sune

PY - 2019

Y1 - 2019

N2 - An improved method, where conventional otoscope investigation of human suspicious otitis media is combined with diffuse reflectance spectroscopy and gas in scattering media absorption spectroscopy (GASMAS) is being developed. Otitis media is one of the most common infectious diseases in children, whose Eustachian tube connecting the middle ear with the nasal cavity is more horizontal than for adults, which leads to impaired fluid drainage. At present, the use of an otoscope to visually observe possible changes in the tympanic membrane appearance is the main diagnostics method for otitis media. Inaccurate diagnosis related to similar symptoms, and the difficulty for small children to describe the condition experienced, frequently leads to over-prescription of antibiotics and alarming increase in bacterial resistance development. More accurate diagnostic methods are highly desirable. Diffuse reflectance spectroscopy is a non-invasive quantitative spectroscopic technique that enables to objectively quantify changes in the hemoglobin content of the tympanic membrane related to inflammation. If an infection is present, the ventilatory function of the Eustachian tube is frequently impaired and the middle-ear cavity will be filled with fluid. GASMAS, a non-invasive detection method, can non-invasively determine if gas is replaced by fluid in the middle-ear cavity.

AB - An improved method, where conventional otoscope investigation of human suspicious otitis media is combined with diffuse reflectance spectroscopy and gas in scattering media absorption spectroscopy (GASMAS) is being developed. Otitis media is one of the most common infectious diseases in children, whose Eustachian tube connecting the middle ear with the nasal cavity is more horizontal than for adults, which leads to impaired fluid drainage. At present, the use of an otoscope to visually observe possible changes in the tympanic membrane appearance is the main diagnostics method for otitis media. Inaccurate diagnosis related to similar symptoms, and the difficulty for small children to describe the condition experienced, frequently leads to over-prescription of antibiotics and alarming increase in bacterial resistance development. More accurate diagnostic methods are highly desirable. Diffuse reflectance spectroscopy is a non-invasive quantitative spectroscopic technique that enables to objectively quantify changes in the hemoglobin content of the tympanic membrane related to inflammation. If an infection is present, the ventilatory function of the Eustachian tube is frequently impaired and the middle-ear cavity will be filled with fluid. GASMAS, a non-invasive detection method, can non-invasively determine if gas is replaced by fluid in the middle-ear cavity.

KW - diagnostics

KW - diffuse reflectance spectroscopy

KW - ear infection

KW - GASMAS

KW - otitis media

KW - otoscope

U2 - 10.1002/jbio.201800305

DO - 10.1002/jbio.201800305

M3 - Article

C2 - 30719866

AN - SCOPUS:85062340251

VL - 12

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 6

M1 - e201800305

ER -