Towards industrial pentose-fermenting yeast strains

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Bibtex

@article{fbc12fbe057b4d5eb6baccc730f65b39,
title = "Towards industrial pentose-fermenting yeast strains",
abstract = "Production of bioethanol from forest and agricultural products requires a fermenting organism that converts all types of sugars in the raw material to ethanol in high yield and with a high rate. This review summarizes recent research aiming at developing industrial strains of Saccharomyces cerevisiae with the ability to ferment all lignocellulose-derived sugars. The properties required from the industrial yeast strains are discussed in relation to four benchmarks: (1) process water economy, (2) inhibitor tolerance, (3) ethanol yield, and (4) specific ethanol productivity. Of particular importance is the tolerance of the fermenting organism to fermentation inhibitors formed during fractionation/pretreatment and hydrolysis of the raw material, which necessitates the use of robust industrial strain background. While numerous metabolic engineering strategies have been developed in laboratory yeast strains, only a few approaches have been realized in industrial strains. The fermentation performance of the existing industrial pentose-fermenting S. cerevisiae strains in lignocellulose hydrolysate is reviewed. Ethanol yields of more than 0.4 g ethanol/g sugar have been achieved with several xylose-fermenting industrial strains such as TMB 3400, TMB 3006, and 424A(LNF-ST), carrying the heterologous xylose utilization pathway consisting of xylose reductase and xylitol dehydrogenase, which demonstrates the potential of pentose fermentation in improving lignocellulosic ethanol production.",
author = "B{\"a}rbel Hahn-H{\"a}gerdal and Kaisa Karhumaa and Cesar Fonseca and Isabel Spencer-Martins and Marie-Francoise Gorwa-Grauslund",
year = "2007",
doi = "10.1007/s00253-006-0827-2",
language = "English",
volume = "74",
pages = "937--953",
journal = "Applied Microbiology and Biotechnology",
issn = "1432-0614",
publisher = "Springer",
number = "5",

}