Tracing Renal Cell Carcinomas back to the Nephron

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Renal cell carcinomas (RCCs) are a heterogeneous group of tumors derived from the epithelial cells of the nephron. In recent years the genetic landscape of these tumors has been detailed, leading to progress in mouse modeling of the human disease. In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to renal insults. Integrating these research fields may provide a deeper understanding of renal tumor initiation and progression, and provide leads that can be conveyed into mouse models that faithfully recapitulate the different RCC subtypes. We summarize here the genetic lesions and molecular pathways that define RCC subtypes and discuss how these relate to cell-of-origin and renal repair programs.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Cancer och onkologi
Originalspråkengelska
Sidor (från-till)472-484
TidskriftTrends in Cancer
Volym4
Utgåva nummer7
Tidigt onlinedatum2018 jun 5
StatusPublished - 2018 jul
PublikationskategoriForskning
Peer review utfördJa