Traffic-Related Air Pollution as a Risk Factor for Dementia: No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort

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Standard

Traffic-Related Air Pollution as a Risk Factor for Dementia : No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort. / Oudin, Anna; Andersson, John; Sundström, Anna; Adolfsson, Annelie Nordin; Åström, Daniel Oudin; Adolfsson, Rolf; Forsberg, Bertil; Nordin, Maria.

Alzheimer’s Disease and Air Pollution. Vol. 8 2021. s. 357-364 (Advances in Alzheimer's Disease).

Forskningsoutput: Kapitel i bok/rapport/Conference proceedingKapitel samlingsverk

Harvard

Oudin, A, Andersson, J, Sundström, A, Adolfsson, AN, Åström, DO, Adolfsson, R, Forsberg, B & Nordin, M 2021, Traffic-Related Air Pollution as a Risk Factor for Dementia: No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort. i Alzheimer’s Disease and Air Pollution. vol. 8, Advances in Alzheimer's Disease, s. 357-364. https://doi.org/10.3233/AIAD210029

APA

Oudin, A., Andersson, J., Sundström, A., Adolfsson, A. N., Åström, D. O., Adolfsson, R., Forsberg, B., & Nordin, M. (2021). Traffic-Related Air Pollution as a Risk Factor for Dementia: No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort. I Alzheimer’s Disease and Air Pollution (Vol. 8, s. 357-364). (Advances in Alzheimer's Disease). https://doi.org/10.3233/AIAD210029

CBE

Oudin A, Andersson J, Sundström A, Adolfsson AN, Åström DO, Adolfsson R, Forsberg B, Nordin M. 2021. Traffic-Related Air Pollution as a Risk Factor for Dementia: No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort. I Alzheimer’s Disease and Air Pollution. s. 357-364. (Advances in Alzheimer's Disease). https://doi.org/10.3233/AIAD210029

MLA

Vancouver

Oudin A, Andersson J, Sundström A, Adolfsson AN, Åström DO, Adolfsson R et al. Traffic-Related Air Pollution as a Risk Factor for Dementia: No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort. I Alzheimer’s Disease and Air Pollution. Vol. 8. 2021. s. 357-364. (Advances in Alzheimer's Disease). https://doi.org/10.3233/AIAD210029

Author

Oudin, Anna ; Andersson, John ; Sundström, Anna ; Adolfsson, Annelie Nordin ; Åström, Daniel Oudin ; Adolfsson, Rolf ; Forsberg, Bertil ; Nordin, Maria. / Traffic-Related Air Pollution as a Risk Factor for Dementia : No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort. Alzheimer’s Disease and Air Pollution. Vol. 8 2021. s. 357-364 (Advances in Alzheimer's Disease).

RIS

TY - CHAP

T1 - Traffic-Related Air Pollution as a Risk Factor for Dementia

T2 - No Clear Modifying Effects of APOE ϵ4 in the Betula Cohort

AU - Oudin, Anna

AU - Andersson, John

AU - Sundström, Anna

AU - Adolfsson, Annelie Nordin

AU - Åström, Daniel Oudin

AU - Adolfsson, Rolf

AU - Forsberg, Bertil

AU - Nordin, Maria

PY - 2021

Y1 - 2021

N2 - It is widely known that the apolipoprotein E (APOE) ϵ4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOE ϵ4 carriers than in non-carriers. Air pollution and interaction with APOE ϵ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up. Nitrogen oxide correlate well with fine particulate air pollution levels in the study area. We had full data on air pollution, incidence of AD and vascular dementia (VaD), APOE ϵ4 carrier status, and relevant confounding factors for 1,567 participants. As expected, air pollution was rather clearly associated with dementia incidence. However, there was no evidence for a modifying effect by APOE ϵ4 on the association (p-value for interaction > 0.30 for both total dementia (AD+VaD) and AD). The results from this study do not imply that adverse effects of air pollution on dementia incidence is limited to, or stronger in, APOE ϵ4 carriers than in the total population.

AB - It is widely known that the apolipoprotein E (APOE) ϵ4 allele imposes a higher risk for Alzheimer's disease (AD). Recent evidence suggests that exposure to air pollution is also a risk factor for AD, and results from a few studies indicate that the effect of air pollution on cognitive function and dementia is stronger in APOE ϵ4 carriers than in non-carriers. Air pollution and interaction with APOE ϵ4 on AD risk thus merits further attention. We studied dementia incidence over a 15-year period from the longitudinal Betula study in Northern Sweden. As a marker for long-term exposure to traffic-related air pollution, we used modelled annual mean nitrogen oxide levels at the residential address of the participants at start of follow-up. Nitrogen oxide correlate well with fine particulate air pollution levels in the study area. We had full data on air pollution, incidence of AD and vascular dementia (VaD), APOE ϵ4 carrier status, and relevant confounding factors for 1,567 participants. As expected, air pollution was rather clearly associated with dementia incidence. However, there was no evidence for a modifying effect by APOE ϵ4 on the association (p-value for interaction > 0.30 for both total dementia (AD+VaD) and AD). The results from this study do not imply that adverse effects of air pollution on dementia incidence is limited to, or stronger in, APOE ϵ4 carriers than in the total population.

KW - Air pollution

KW - Alzheimer's disease

KW - apolipoprotein E

KW - dementia

U2 - 10.3233/AIAD210029

DO - 10.3233/AIAD210029

M3 - Book chapter

AN - SCOPUS:85110853331

SN - 978-1-64368-158-0

VL - 8

T3 - Advances in Alzheimer's Disease

SP - 357

EP - 364

BT - Alzheimer’s Disease and Air Pollution

ER -