Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

The etiology of most neurological disorders is poorly understood and current treatments are largely ineffective. New ideas and concepts are therefore vitally important for future research in this area. This review explores the concept that dysregulation of transposable elements (TEs) contributes to the appearance and pathology of neurodevelopmental and neurodegenerative disorders. Despite TEs making up at least half of the human genome, they are vastly understudied in relation to brain disorders. However, recent advances in sequencing technologies and gene editing approaches are now starting to unravel the pathological role of TEs. Aberrant activation of TEs has been found in many neurological disorders; the resulting pathogenic effects, which include alterations of gene expression, neuroinflammation, and direct neurotoxicity, are starting to be resolved. An increased understanding of the relationship between TEs and pathological processes in the brain improves the potential for novel diagnostics and interventions for brain disorders.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper
  • Neurologi
Originalspråkengelska
Sidor (från-till)610-623
Antal sidor14
TidskriftTrends in Genetics
Volym36
Utgåva nummer8
Tidigt onlinedatum2020 jun 1
StatusPublished - 2020 aug 1
PublikationskategoriForskning
Peer review utfördJa