Trigeminal fibre collaterals storing substance P and calcitonin gene-related peptide associate with ganglion cells containing choline acetyltransferase and vasoactive intestinal polypeptide in the sphenopalatine ganglion of the rat. An axon reflex modulating parasympathetic ganglionic activity?

TY - JOUR

T1 - Trigeminal fibre collaterals storing substance P and calcitonin gene-related peptide associate with ganglion cells containing choline acetyltransferase and vasoactive intestinal polypeptide in the sphenopalatine ganglion of the rat. An axon reflex modulating parasympathetic ganglionic activity?

AU - Suzuki, N

AU - Hardebo, Jan Erik

AU - Owman, Christer

PY - 1989

Y1 - 1989

N2 - In immunohistochemical studies on rat two types of nerve fibres, both showing substance P and calcitonin gene-related peptide-like immunoreactivity, have been localized in the sphenopalatine ganglion, the principal cells of which contain both vasoactive intestinal polypeptide and choline acetyltransferase. One fine-calibre fibre type forms basket-like arrangements around approximately 3-5% of the principal neurons, whereas another, more coarse type traverses the ganglion without making contacts with the ganglion cells. By transection of nerves connecting with the ganglion, in combination with retrograde tracing experiments, it was concluded that the fine-calibre fibres exclusively come from the trigeminal ganglion, whereas the second type in addition, and mainly, originate in the internal carotid ganglion which is situated along the greater superficial petrosal nerve and the pterygoid nerve at their junction with the internal carotid nerve. The brain vasculature was shown to be one target structure for the innervated principal cells in the sphenopalatine ganglion. The arrangement provides the functional possibility for a modulatory interaction between the autonomic and sensory systems, thus resembling an axon reflex mechanism in the peripheral nervous system.

AB - In immunohistochemical studies on rat two types of nerve fibres, both showing substance P and calcitonin gene-related peptide-like immunoreactivity, have been localized in the sphenopalatine ganglion, the principal cells of which contain both vasoactive intestinal polypeptide and choline acetyltransferase. One fine-calibre fibre type forms basket-like arrangements around approximately 3-5% of the principal neurons, whereas another, more coarse type traverses the ganglion without making contacts with the ganglion cells. By transection of nerves connecting with the ganglion, in combination with retrograde tracing experiments, it was concluded that the fine-calibre fibres exclusively come from the trigeminal ganglion, whereas the second type in addition, and mainly, originate in the internal carotid ganglion which is situated along the greater superficial petrosal nerve and the pterygoid nerve at their junction with the internal carotid nerve. The brain vasculature was shown to be one target structure for the innervated principal cells in the sphenopalatine ganglion. The arrangement provides the functional possibility for a modulatory interaction between the autonomic and sensory systems, thus resembling an axon reflex mechanism in the peripheral nervous system.

KW - vasoactive intestinal polypeptide

KW - VIP

KW - CGRP

KW - calcitonin gene-related peptide

KW - ChAT

KW - choline acetyltransferase

KW - FITC

KW - fluorescein isothiocyanate

KW - GSPN

KW - greater superficial petrosal nerve

KW - PN

KW - pterygoid nerve

KW - SP

KW - substance P

KW - SPG

KW - sphenopalatine ganglion

KW - TB

KW - True Blue

KW - TRITC

KW - tetramethyl rhodamine isothiocyanate

U2 - 10.1016/0306-4522(89)90154-1

DO - 10.1016/0306-4522(89)90154-1

M3 - Article

VL - 30

SP - 595

EP - 604

JO - Neuroscience

JF - Neuroscience

SN - 1873-7544

IS - 3

ER -