TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells

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TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells. / Brattås, Per Ludvik; Jönsson, Marie E.; Fasching, Liana; Nelander Wahlestedt, Jenny; Shahsavani, Mansoureh; Falk, Ronny; Falk, Anna Helena; Jern, Patric; Parmar, Malin; Jakobsson, Johan.

I: Cell Reports, Vol. 18, Nr. 1, 03.01.2017, s. 1-11.

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Brattås, Per Ludvik ; Jönsson, Marie E. ; Fasching, Liana ; Nelander Wahlestedt, Jenny ; Shahsavani, Mansoureh ; Falk, Ronny ; Falk, Anna Helena ; Jern, Patric ; Parmar, Malin ; Jakobsson, Johan. / TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells. I: Cell Reports. 2017 ; Vol. 18, Nr. 1. s. 1-11.

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TY - JOUR

T1 - TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells

AU - Brattås, Per Ludvik

AU - Jönsson, Marie E.

AU - Fasching, Liana

AU - Nelander Wahlestedt, Jenny

AU - Shahsavani, Mansoureh

AU - Falk, Ronny

AU - Falk, Anna Helena

AU - Jern, Patric

AU - Parmar, Malin

AU - Jakobsson, Johan

PY - 2017/1/3

Y1 - 2017/1/3

N2 - Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.

AB - Endogenous retroviruses (ERVs), which make up 8% of the human genome, have been proposed to participate in the control of gene regulatory networks. In this study, we find a region- and developmental stage-specific expression pattern of ERVs in the developing human brain, which is linked to a transcriptional network based on ERVs. We demonstrate that almost 10,000, primarily primate-specific, ERVs act as docking platforms for the co-repressor protein TRIM28 in human neural progenitor cells, which results in the establishment of local heterochromatin. Thereby, TRIM28 represses ERVs and consequently regulates the expression of neighboring genes. These results uncover a gene regulatory network based on ERVs that participates in control of gene expression of protein-coding transcripts important for brain development.

KW - epigenetics

KW - gene regulation

KW - human development

KW - neural stem cells

KW - transposable elements

UR - http://www.scopus.com/inward/record.url?scp=85009112234&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2016.12.010

DO - 10.1016/j.celrep.2016.12.010

M3 - Article

VL - 18

SP - 1

EP - 11

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 1

ER -