Triple visual hemifield maps in a case of optic chiasm hypoplasia

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Abstract

In humans, each hemisphere comprises an overlay of two visuotopic maps of the contralateral visual field, one from each eye. Is the capacity of the visual cortex limited to these two maps or are plastic mechanisms available to host more maps? We determined the cortical organization of the visual field maps in a rare individual with chiasma hypoplasia, where visual cortex plasticity is challenged to accommodate three hemifield maps. Using high-resolution fMRI at 7T and diffusion-weighted MRI at 3T, we found three hemiretinal inputs, instead of the normal two, to converge onto the left hemisphere. fMRI-based population receptive field mapping of the left V1–V3 at 3T revealed three superimposed hemifield representations in the left visual cortex, i.e. two representations of opposing visual hemifields from the left eye and one right hemifield representation from the right eye. We conclude that developmental plasticity including the re-wiring of local intra- and cortico-cortical connections is pivotal to support the coexistence and functioning of three hemifield maps within one hemisphere.

Detaljer

Författare
  • Khazar Ahmadi
  • Alessio Fracasso
  • Robert J. Puzniak
  • Andre D. Gouws
  • Renat Yakupov
  • Oliver Speck
  • Joern Kaufmann
  • Franco Pestilli
  • Serge O. Dumoulin
  • Antony B. Morland
  • Michael B. Hoffmann
Enheter & grupper
Externa organisationer
  • Otto von Guericke University Magdeburg
  • University Medical Center Utrecht
  • University of Glasgow
  • University of York
  • German Center for Neurodegenerative Diseases
  • Leibniz Institute for Neurobiology
  • Indiana University
  • Utrecht University
  • Spinoza Centre for Neuroimaging
  • Vrije Universiteit Amsterdam
  • Center for Behavioral Brain Sciences
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Fysiologi
  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Artikelnummer116822
TidskriftNeuroImage
Volym215
StatusPublished - 2020 jul 15
PublikationskategoriForskning
Peer review utfördJa