Triterpenoid CDDO-methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer's disease

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Oxidative stress is one of the earliest events in the pathogenesis of Alzheimer's disease (AD) and can markedly exacerbate amyloid pathology. Modulation of antioxidant and anti-inflammatory pathways represents an important approach for AD therapy. Synthetic triterpenoids have been found to facilitate antioxidant response and reduce inflammation in several models. We investigated the effect of the triterpenoid, 2-Cyano-3,12-Dioxooleana-1,9-Dien-28-Oic acid-MethylAmide (CDDO-MA) in Tg19959 mice, which carry the human amyloid precursor protein with two mutations. These mice develop memory impairments and amyloid plaques as early as 2-3 months of age. CDDO-MA was provided with chow (800 mg/kg) from 1 to 4 months of age. CDDO-MA significantly improved spatial memory retention and reduced plaque burden, Aβ42 levels, microgliosis, and oxidative stress in Tg19959 mice.

Detaljer

Författare
  • Magali Dumont
  • Elizabeth Wille
  • Noel Y. Calingasan
  • Davide Tampellini
  • Charlotte Williams
  • Gunnar K. Gouras
  • Karen Liby
  • Michael Sporn
  • M. Flint Beal
  • Michael T. Lin
Externa organisationer
  • Weill Cornell Medical College
  • Dartmouth College
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Neurovetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)502-512
TidskriftJournal of Neurochemistry
Volym109
Utgåva nummer2
StatusPublished - 2009 apr
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa