Tuning the protein phosphorylation by receptor type protein tyrosine phosphatase epsilon (PTPRE) in normal and cancer cells

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Tuning the protein phosphorylation by receptor type protein tyrosine phosphatase epsilon (PTPRE) in normal and cancer cells. / Liang, Jinping; Shi, Jun; Wang, Na; Zhao, Hui; Sun, Jianmin.

I: Journal of Cancer, Vol. 10, Nr. 1, 2019, s. 105-111.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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TY - JOUR

T1 - Tuning the protein phosphorylation by receptor type protein tyrosine phosphatase epsilon (PTPRE) in normal and cancer cells

AU - Liang, Jinping

AU - Shi, Jun

AU - Wang, Na

AU - Zhao, Hui

AU - Sun, Jianmin

PY - 2019

Y1 - 2019

N2 - Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has been studied in osteoclast cells, nerve cells, hematopoietic cells, cancer cells and others, and it has different functions among various tissues. In this review, we summarized the current knowledge about the regulation of PTPRE on cellular signal transduction and its function under normal and pathological conditions.

AB - Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has been studied in osteoclast cells, nerve cells, hematopoietic cells, cancer cells and others, and it has different functions among various tissues. In this review, we summarized the current knowledge about the regulation of PTPRE on cellular signal transduction and its function under normal and pathological conditions.

KW - Cancer

KW - PTPRE

KW - Signaling

KW - Tyrosine phosphatase

U2 - 10.7150/jca.27633

DO - 10.7150/jca.27633

M3 - Article

VL - 10

SP - 105

EP - 111

JO - Journal of Skin Cancer

T2 - Journal of Skin Cancer

JF - Journal of Skin Cancer

SN - 2090-2905

IS - 1

ER -