Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding

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Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding. / Van Den Bosch, T.; Verbakel, J. Y.; Valentin, L.; Wynants, L.; De Cock, B.; Pascual, M. A.; Leone, F. P.G.; Sladkevicius, P.; Alcazar, J. L.; Votino, A.; Fruscio, R.; Lanzani, C.; Van Holsbeke, C.; Rossi, A.; Jokubkiene, L.; Kudla, M.; Jakab, A.; Domali, E.; Epstein, E.; Van Pachterbeke, C.; Bourne, T.; Van Calster, B.; Timmerman, D.

I: Ultrasound in Obstetrics and Gynecology, Vol. 57, Nr. 1, 2021, s. 164-172.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Van Den Bosch, T, Verbakel, JY, Valentin, L, Wynants, L, De Cock, B, Pascual, MA, Leone, FPG, Sladkevicius, P, Alcazar, JL, Votino, A, Fruscio, R, Lanzani, C, Van Holsbeke, C, Rossi, A, Jokubkiene, L, Kudla, M, Jakab, A, Domali, E, Epstein, E, Van Pachterbeke, C, Bourne, T, Van Calster, B & Timmerman, D 2021, 'Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding', Ultrasound in Obstetrics and Gynecology, vol. 57, nr. 1, s. 164-172. https://doi.org/10.1002/uog.22109

APA

Van Den Bosch, T., Verbakel, J. Y., Valentin, L., Wynants, L., De Cock, B., Pascual, M. A., Leone, F. P. G., Sladkevicius, P., Alcazar, J. L., Votino, A., Fruscio, R., Lanzani, C., Van Holsbeke, C., Rossi, A., Jokubkiene, L., Kudla, M., Jakab, A., Domali, E., Epstein, E., ... Timmerman, D. (2021). Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding. Ultrasound in Obstetrics and Gynecology, 57(1), 164-172. https://doi.org/10.1002/uog.22109

CBE

Van Den Bosch T, Verbakel JY, Valentin L, Wynants L, De Cock B, Pascual MA, Leone FPG, Sladkevicius P, Alcazar JL, Votino A, Fruscio R, Lanzani C, Van Holsbeke C, Rossi A, Jokubkiene L, Kudla M, Jakab A, Domali E, Epstein E, Van Pachterbeke C, Bourne T, Van Calster B, Timmerman D. 2021. Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding. Ultrasound in Obstetrics and Gynecology. 57(1):164-172. https://doi.org/10.1002/uog.22109

MLA

Vancouver

Author

Van Den Bosch, T. ; Verbakel, J. Y. ; Valentin, L. ; Wynants, L. ; De Cock, B. ; Pascual, M. A. ; Leone, F. P.G. ; Sladkevicius, P. ; Alcazar, J. L. ; Votino, A. ; Fruscio, R. ; Lanzani, C. ; Van Holsbeke, C. ; Rossi, A. ; Jokubkiene, L. ; Kudla, M. ; Jakab, A. ; Domali, E. ; Epstein, E. ; Van Pachterbeke, C. ; Bourne, T. ; Van Calster, B. ; Timmerman, D. / Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding. I: Ultrasound in Obstetrics and Gynecology. 2021 ; Vol. 57, Nr. 1. s. 164-172.

RIS

TY - JOUR

T1 - Typical ultrasound features of various endometrial pathologies described using International Endometrial Tumor Analysis (IETA) terminology in women with abnormal uterine bleeding

AU - Van Den Bosch, T.

AU - Verbakel, J. Y.

AU - Valentin, L.

AU - Wynants, L.

AU - De Cock, B.

AU - Pascual, M. A.

AU - Leone, F. P.G.

AU - Sladkevicius, P.

AU - Alcazar, J. L.

AU - Votino, A.

AU - Fruscio, R.

AU - Lanzani, C.

AU - Van Holsbeke, C.

AU - Rossi, A.

AU - Jokubkiene, L.

AU - Kudla, M.

AU - Jakab, A.

AU - Domali, E.

AU - Epstein, E.

AU - Van Pachterbeke, C.

AU - Bourne, T.

AU - Van Calster, B.

AU - Timmerman, D.

PY - 2021

Y1 - 2021

N2 - Objective: To describe the ultrasound features of different endometrial and other intracavitary pathologies inpre- and postmenopausal women presenting with abnormal uterine bleeding, using the International Endometrial Tumor Analysis (IETA) terminology. Methods: This was a prospective observational multicenter study of consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler and fluid-instillation sonography were performed. Endometrial sampling was performed according to each center's local protocol. The histological endpoints were cancer, atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia (EIN), endometrial atrophy, proliferative or secretory endometrium, endometrial hyperplasia without atypia, endometrial polyp, intracavitary leiomyoma and other. For fluid-instillation sonography, the histological endpoints were endometrial polyp, intracavitary leiomyoma and cancer. For each histological endpoint, we report typical ultrasound features using the IETA terminology. Results: The database consisted of 2856 consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler was performed in all cases and fluid-instillation sonography in 1857. In 2216 women, endometrial histology was available, and these comprised the study population. Median age was 49 years (range, 19–92 years), median parity was 2 (range, 0–10) and median body mass index was 24.9 kg/m2 (range, 16.0–72.1 kg/m2). Of the study population, 843 (38.0%) women were postmenopausal. Endometrial polyps were diagnosed in 751 (33.9%) women, intracavitary leiomyomas in 223 (10.1%) and endometrial cancer in 137 (6.2%). None (0% (95% CI, 0.0–5.5%)) of the 66 women with endometrial thickness < 3 mm had endometrial cancer or atypical hyperplasia/EIN. Endometrial cancer or atypical hyperplasia/EIN was found in three of 283 (1.1% (95% CI, 0.4–3.1%)) endometria with a three-layer pattern, in three of 459 (0.7% (95% CI, 0.2–1.9%)) endometria with a linear endometrial midline and in five of 337 (1.5% (95% CI, 0.6–3.4%)) cases with a single vessel without branching on unenhanced ultrasound. Conclusions: The typical ultrasound features of endometrial cancer, polyps, hyperplasia and atrophy and intracavitary leiomyomas, are described using the IETA terminology. The detection of some easy-to-assess IETA features (i.e. endometrial thickness < 3 mm, three-layer pattern, linear midline and single vessel without branching) makes endometrial cancer unlikely.

AB - Objective: To describe the ultrasound features of different endometrial and other intracavitary pathologies inpre- and postmenopausal women presenting with abnormal uterine bleeding, using the International Endometrial Tumor Analysis (IETA) terminology. Methods: This was a prospective observational multicenter study of consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler and fluid-instillation sonography were performed. Endometrial sampling was performed according to each center's local protocol. The histological endpoints were cancer, atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia (EIN), endometrial atrophy, proliferative or secretory endometrium, endometrial hyperplasia without atypia, endometrial polyp, intracavitary leiomyoma and other. For fluid-instillation sonography, the histological endpoints were endometrial polyp, intracavitary leiomyoma and cancer. For each histological endpoint, we report typical ultrasound features using the IETA terminology. Results: The database consisted of 2856 consecutive women presenting with abnormal uterine bleeding. Unenhanced sonography with color Doppler was performed in all cases and fluid-instillation sonography in 1857. In 2216 women, endometrial histology was available, and these comprised the study population. Median age was 49 years (range, 19–92 years), median parity was 2 (range, 0–10) and median body mass index was 24.9 kg/m2 (range, 16.0–72.1 kg/m2). Of the study population, 843 (38.0%) women were postmenopausal. Endometrial polyps were diagnosed in 751 (33.9%) women, intracavitary leiomyomas in 223 (10.1%) and endometrial cancer in 137 (6.2%). None (0% (95% CI, 0.0–5.5%)) of the 66 women with endometrial thickness < 3 mm had endometrial cancer or atypical hyperplasia/EIN. Endometrial cancer or atypical hyperplasia/EIN was found in three of 283 (1.1% (95% CI, 0.4–3.1%)) endometria with a three-layer pattern, in three of 459 (0.7% (95% CI, 0.2–1.9%)) endometria with a linear endometrial midline and in five of 337 (1.5% (95% CI, 0.6–3.4%)) cases with a single vessel without branching on unenhanced ultrasound. Conclusions: The typical ultrasound features of endometrial cancer, polyps, hyperplasia and atrophy and intracavitary leiomyomas, are described using the IETA terminology. The detection of some easy-to-assess IETA features (i.e. endometrial thickness < 3 mm, three-layer pattern, linear midline and single vessel without branching) makes endometrial cancer unlikely.

KW - cancer

KW - diagnosis

KW - endometrium

KW - hyperplasia

KW - IETA

KW - leiomyoma

KW - polyp

KW - sonohysterography

KW - ultrasonography

U2 - 10.1002/uog.22109

DO - 10.1002/uog.22109

M3 - Article

C2 - 32484286

AN - SCOPUS:85098501592

VL - 57

SP - 164

EP - 172

JO - Ultrasound in Obstetrics & Gynecology

JF - Ultrasound in Obstetrics & Gynecology

SN - 1469-0705

IS - 1

ER -