Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size. Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10 000 times faster than standard methods with preserved analytic accuracy.

Detaljer

Författare
  • Björn Nilsson
  • Mikael Johansson
  • Fatima Al-Shahrour
  • Anne E. Carpenter
  • Benjamin L. Ebert
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Bioinformatik och systembiologi
Originalspråkengelska
Sidor (från-till)1078-1079
TidskriftBioinformatics
Volym25
Utgivningsnummer8
StatusPublished - 2009
PublikationskategoriForskning
Peer review utfördJa