URB937, a peripherally-restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibers in rats.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

To determine if an inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) can counteract the changes in urodynamic parameters and bladder afferent activities induced by intravesical prostaglandin E2 (PGE2 )-instillation, we studied effects of URB937, a peripherally-restricted FAAH inhibitor, on single-unit afferent activity (SAA) during PGE2 -induced bladder overactivity in rats.

Detaljer

Författare
  • Naoki Aizawa
  • Giorgio Gandaglia
  • Petter Hedlund
  • Tetsuya Fujimura
  • Hiroshi Fukuhara
  • Francesco Montorsi
  • Yukio Homma
  • Yasuhiko Igawa
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Farmakologi och toxikologi
Originalspråkengelska
TidskriftBJU International
Tidigt onlinedatum2015 jul 18
StatusPublished - 2015
PublikationskategoriForskning
Peer review utfördJa