Urinary bisphenol a, f and s levels and semen quality in young adult danish men

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Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are struc-turally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross– sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18–20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concen-tration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile–divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre–pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.


  • Thea Emily Benson
  • Anne Gaml-Sørensen
  • Andreas Ernst
  • Nis Brix
  • Karin Sørig Hougaard
  • Katia Keglberg Hærvig
  • Jens Peter Ellekilde Bonde
  • Sandra Søgaard Tøttenborg
  • Christian H. Lindh
  • Cecilia Høst Ramlau-Hansen
  • Gunnar Toft
Enheter & grupper
Externa organisationer
  • Aarhus University
  • Aarhus University Hospital
  • University of Copenhagen
  • National Research Centre for the Working Environment
  • Frederiksberg Hospital
  • Regional Hospital Unit West Jutland

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Miljömedicin och yrkesmedicin
  • Reproduktionsmedicin och gynekologi


Antal sidor12
TidskriftInternational Journal of Environmental Research and Public Health
Utgåva nummer4
StatusPublished - 2021
Peer review utfördJa