Variation in human milk composition is related to differences in milk and infant fecal microbial communities

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Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces. Here, we characterized and contrasted concentrations of milk-borne lactose, protein, and HMOs, and examined their associations with milk and infant fecal microbiomes in samples collected in 11 geographically diverse sites. Although geographical site was strongly associated with milk and infant fecal microbiomes, both sample types assorted into a smaller number of community state types based on shared microbial profiles. Similar to HMOs, concentrations of lactose and protein also varied by geography. Concentrations of HMOs, lactose, and protein were associated with differences in the microbial community structures of milk and infant feces and in the abundance of specific taxa. Taken together, these data suggest that the composition of human milk, even when produced by relatively healthy women, differs based on geographical boundaries and that concentrations of HMOs, lactose, and protein in milk are related to variation in milk and infant fecal microbial communities.


  • Ryan M. Pace
  • Janet E. Williams
  • Bianca Robertson
  • Kimberly A. Lackey
  • Courtney L. Meehan
  • William J. Price
  • James A. Foster
  • Daniel W. Sellen
  • Elizabeth W. Kamau-Mbuthia
  • Egidioh W. Kamundia
  • Samwel Mbugua
  • Sophie E. Moore
  • Andrew M. Prentice
  • Debela G. Kita
  • Linda J. Kvist
  • Gloria E. Otoo
  • Lorena Ruiz
  • Juan M. Rodríguez
  • Rossina G. Pareja
  • Mark A. McGuire
  • Och 2 andra
  • Lars Bode
  • Michelle K. McGuire
Enheter & grupper
Externa organisationer
  • University of Idaho
  • University of California, San Diego
  • Washington State University
  • University of Toronto
  • Egerton University
  • University of Ghana
  • Complutense University of Madrid
  • King's College London
  • London School of Hygiene and Tropical Medicine
  • Hawassa University
  • CSIC Instituto de Productos Lácteos de Asturias (IPLA)
  • Instituto de Investigación Sanitaria del Principado de Asturias (ISPA)
  • Nutrition Research Institute Lima

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Mikrobiologi inom det medicinska området


Utgåva nummer6
StatusPublished - 2021 jun 1
Peer review utfördJa