Venoarterial Extracorporeal Membrane Oxygenation After Surgical Repair of Type A Aortic Dissection

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

Venoarterial (VA) extracorporeal membrane oxygenation (ECMO) support for postcardiotomy cardiogenic shock (PCS) in patients undergoing surgery for acute type A aortic dissection (TAAD) is controversial and the available evidence is confined to limited case series. We aimed to evaluate the impact of this salvage therapy in this patient population. Between January 2010 and March 2018, all TAAD patients receiving VA-ECMO for PCS were retrieved from the PC-ECMO registry. Hospital mortality and other secondary outcomes were compared with PCS patients undergoing surgery for other cardiac pathologies and treated with VA-ECMO. Among the 781 patients in the PC-ECMO registry, 62 (7.9%) underwent TAAD repair and required VA-ECMO support for PCS. In-hospital mortality accounted for 46 (74.2%) patients, while 23 (37.1%) were successfully weaned from VA-ECMO. No significant differences were observed between the TAAD and non-TAAD cohorts with reference to in-hospital mortality (74.2% vs 63.4%, p = 0.089). However, patients in the TAAD group had a higher rate of neurological events (33.9% vs 17.6%, p = 0.002), but similar rates of reoperation for bleeding/tamponade (48.4% vs 41.5%, p = 0.29), transfusion of ≥10 red blood cell units (77.4% vs 69.5%, p = 0.19), new-onset dialysis (56.7% vs 53.1%, p = 0.56), and other secondary outcomes. VA-ECMO provides a valid support for patients affected by PCS after surgery for TAAD.

Detaljer

Författare
  • Giovanni Mariscalco
  • Antonio Fiore
  • Sigurdur Ragnarsson
  • Zein El-Dean
  • Kristján Jónsson
  • Magnus Dalén
  • Thomas Fux
  • Vito G. Ruggieri
  • Giuseppe Gatti
  • Tatu Juvonen
  • Svante Zipfel
  • Angelo M. Dell'Aquila
  • Andrea Perrotti
  • Karl Bounader
  • Nicla Settembre
  • Antonio Loforte
  • Ugolino Livi
  • Marek Pol
  • Cristiano Spadaccio
  • Matteo Pettinari
  • Daniel Reichart
  • Khalid Alkhamees
  • Henryk Welp
  • Daniele Maselli
  • Artur Lichtenberg
  • Fausto Biancari
  • the PC-ECMO group
Enheter & grupper
Externa organisationer
  • Glenfield Hospital
  • Henri Mondor Hospital
  • Sahlgrenska University Hospital
  • Karolinska University Hospital
  • Hopital Robert Debre CHU de Reims
  • Ospedali riuniti di Trieste
  • Helsinki University Central Hospital
  • University of Oulu
  • University Medical Center Hamburg-Eppendorf
  • Universitätsklinikum Münster
  • University Hospital Jean Minjoz
  • Pontchaillou University Hospital
  • University Hospital of Nancy
  • St. Orsola-Malpighi University Hospital
  • University Hospital of Udine
  • Institute for Clinical and Experimental Medicine
  • Ziekenhuis Oost-Limburg
  • Prince Sultan Cardiac Center
  • Universitätsklinikum Düsseldorf
  • Turku University Hospital
  • Golden Jubilee National Hospital
  • S. Anna Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Kardiologi
  • Kirurgi
Originalspråkengelska
TidskriftAmerican Journal of Cardiology
StatusE-pub ahead of print - 2020 mar 31
PublikationskategoriForskning
Peer review utfördJa