Ventilation-Perfusion SPECT with Tc-99m-DTPA Versus Technegas: A Head-to-Head Study in Obstructive and Nonobstructive Disease

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Lung scintigraphy is primarily used to diagnose pulmonary embolism. Ventilation imaging is often performed using Tc-99m-DTPA or Technegas, an ultrafine dispersion of Tc-99m-labeled carbon. Despite the common use of these radioaerosols, they have not been compared in an intraindividual study, and not with ventilation-perfusion (V/P) SPECT. The aim of the present head-to-head study was to systematically investigate differences in ventilation studies performed with Tc-99m-diethylenetriaminepentaacetate (DTPA) and Technegas. Methods: Sixty-three patients, 28 without and 35 with obstructive lung disease, were examined with V/P SPECT using both Tc-99m-DTPA and Technegas. V/P SPECT images were randomized and assessed independently by 2 masked physicians according to a predefined scoring system. A paired comparison was performed using the Wilcoxon signed-rank test. Results: In both obstructive and nonobstructive disease, the overall unevenness of radiotracer deposition and the degree of central deposition were more pronounced in Tc-99m-DTPA than Technegas studies. Because of better peripheral penetration, the extent of reverse mismatch was less when Technegas was used. Additionally, in obstructive disease, the degree of focal deposition in distal airways was more pronounced with Tc-99m-DTPA. Mismatched perfusion defects were more frequently found with Technegas in obstructive disease. Conclusion: This intraindividual comparative study shows that Technegas is the preferred radioaerosol, particularly in obstructive disease.


Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Lungmedicin och allergi


Sidor (från-till)735-741
TidskriftJournal of Nuclear Medicine
Utgåva nummer5
StatusPublished - 2010
Peer review utfördJa

Relaterad forskningsoutput

Jonas Jögi, 2011, Department of Clinical Physiology, Lund University. 130 s.

Forskningsoutput: AvhandlingDoktorsavhandling (sammanläggning)

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