Ventricular high-rate episodes predict increased mortality in heart failure patients treated with cardiac resynchronization therapy.
Forskningsoutput: Tidskriftsbidrag › Artikel i vetenskaplig tidskrift
Abstract Objectives. Cardiac Resynchronization Therapy (CRT) for heart-failure patients has a well-documented positive effect, but the overall mortality in this group remains high. This study aimed to explore whether additional information from the device post-implant (occurrence of ventricular high-rate episodes), could add prognostic value for patients on CRT-pacemaker (CRT-P) treatment. Design. Clinical data and device-interrogation data were retrospectively gathered from the medical records of 220 patients treated with CRT-P. Ventricular high-rate (VHR) episodes were defined as a ventricular rate ≥ 180 beats per minute. The primary outcome was 5-year mortality. Results. During follow-up, 132 patients (60%) died or underwent heart transplant. Overall, the 5-year mortality rate was 52%; 77% for patients with VHR during the first year of follow-up and 48% for patients without VHR during the first year of follow-up (p = 0.001). In a multivariate model, the occurrence of VHR episodes was an independent predictor of 5-year mortality (HR 9.96, p = 0.022). The most common cause of death was heart failure, and death from arrhythmia did not differ between groups (p = 0.065). Conclusions. In heart-failure patients with CRT-P therapy, occurrence of VHR episodes within the first year post-implant was an independent predictor of higher 5-year mortality and inferior long-term survival, but not of death from malignant arrhythmia.
|Enheter & grupper|
Ämnesklassifikation (UKÄ) – OBLIGATORISK
|Tidskrift||Scandinavian Cardiovascular Journal|
|Status||Published - 2015|
|Peer review utförd||Ja|
Non-invasive Prediction of Cardiac Resynchronization Therapy. Focus on the role of atrial fibrillation, device-diagnostics and ECG-based risk markersJonatan Jacobsson, 2020, Lund: Lund University, Faculty of Medicine. 88 s.
Forskningsoutput: Avhandling › Doktorsavhandling (sammanläggning)