VERANDERUNG DER INSULINSEKRETION ISOLIERTER LANGERHANS'SCHER INSELN DURCH BEHANDLUNG MIT NEURAMINIDASE

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Abstract

Treatment of pancreatic islets from ob/ob-mice with bacterial neuraminidase (0.8 to 40 mU/ml) resulted in a significant decrease of the sialic acid content and of the secretory response to glucose. The inhibitory effect on the glucose stimulated insulin release was reproduced with different batches of neuraminidase from Clostridium perfringens and Vibrio cholera. Treatment with neuraminidase affected neither the insulin content of the islets nor the potentiating effect of theophylline in the presence of 20 mM glucose. The results suggest that sialic acid plays a role in the mechanism of insulin release and that the inhibitory effect of sialic acid depletion is overcome by theophylline. (30 references.)

Detaljer

Författare
Externa organisationer
  • Umeå University
Originalspråktyska
Sidor (från-till)375-383
Antal sidor9
TidskriftActa Biologica et Medica Germanica
Volym32
Utgåva nummer4
StatusPublished - 1974 jan 1
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa