Vibratory perception threshold in young and middle-aged patients at high risk of knee osteoarthritis compared to controls

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Objective Vibratory perception threshold (VPT) is impaired in patients with knee osteoarthritis (OA). It is, however, not known if sensory deficits precede or follow as a consequence of OA. The aim of this study was to investigate VPT in 2 independent groups of patients with high risk of future OA (young anterior cruciate ligament [ACL]-injured patients and middle-aged meniscectomized patients) and compare them to age-matched controls. Methods. VPT was assessed at the medial malleolus (MM) and medial femoral condyle (MFC) in 2 independent groups of patients and matched controls: ACL- injured patients (n = 39, mean +/- SD age 24.0 +/- 5.2 years, mean +/- SD BMI 24.0 +/- 2.9 kg/m(2), mean +/- SD time since injury 21.9 +/- 21.6 months) and controls (n = 28, mean +/- SD age 25.6 +/- 4.4 years, mean +/- SD BMI 23.6 +/- 2.2 kg/m(2)), and meniscectomized patients (n = 22, mean +/- SD age 49.6 +/- 4.8 years, mean +/- SD BMI 24.7 +/- 2.7 kg/m(2), mean +/- SD time since surgery 49.6 +/- 5.0 months) and controls (n = 25, mean +/- SD age 49.4 +/- 5.2 years, mean +/- SD BMI 25.2 +/- 4.9 kg/m(2)). Results. ACL- injured patients had a better VPT than controls at the MM (P = 0.030), which persisted after adjusting for age and sex (P = 0.034). At the MFC, there was a similar trend in favor of ACL injured patients (unadjusted P = 0.093, adjusted P = 0.122). No differences were seen in VPT at theMMbetween meniscectomized patients and controls, whereas there was a tendency for better VPT in meniscectomized patients at the MFC (unadjusted P = 0.085, adjusted P = 0.092). Conclusion. Impaired vibratory sensation could not be confirmed in 2 independent groups of patients compared to age-matched controls, suggesting that impaired vibratory sense is not present in knee- injured patients at high risk or in the very early phase of knee OA.


  • Jonas Bloch Thorlund
  • Najia Shakoor
  • Eva Ageberg
  • Louise Fleng Sandal
  • Joel A. Block
  • Ewa Roos
Enheter & grupper

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Reumatologi och inflammation
Sidor (från-till)144-148
TidskriftArthritis Care and Research
Utgåva nummer1
StatusPublished - 2012
Peer review utfördJa