Viral blips during suppressive antiretroviral treatment are associated with high baseline HIV-1 RNA levels

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Abstract

Background: Many HIV-1-infected patients on suppressive antiretroviral therapy (ART) have transiently elevated HIV RNA levels. The clinical significance of these viral blips is uncertain. We have determined the incidence of blips and investigated important associations in the Swedish HIV-cohort. Methods: HIV-1-infected ART naïve adults who commenced ART 2007-2013 were retrospectively included. Viral blips were defined as a transient viral load between 50 and 500 copies/mL Subjects not suppressed after six months on ART were excluded. Results: Viral blips were found in 76/735 included subjects (10.3%) and in 90/4449 samples (2.0%). Median blip viral load was 76 copies/mL (range 56-138). Median follow-up time was 170weeks (range 97-240). Baseline viral load was higher in subjects with viral blips (median log10 4.85 copies/mL) compared with subjects without blips (median log10 4.55 copies/mL) (p < 0.01). There was a significant association between viral blips and risk for subsequent virological failure (p < 0.001). Conclusions: The Swedish national HIV-cohort has a low incidence of viral blips (10%). Blips were associated with high baseline viral load and an increased risk of subsequent virological failure.

Detaljer

Författare
  • Erik Sörstedt
  • Staffan Nilsson
  • Anders Blaxhult
  • Magnus Gisslén
  • Leo Flamholc
  • Anders Sönnerborg
  • Aylin Yilmaz
Externa organisationer
  • Chalmers Tekniska Högskola
  • Södersjukhuset
  • Göteborgs universitet
  • Skåne University Hospital
  • Karolinska University Hospital
  • Karolinska Institute
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Infektionsmedicin

Nyckelord

Originalspråkengelska
Artikelnummer305
TidskriftBMC Infectious Diseases
Volym16
Utgåva nummer1
StatusPublished - 2016 jun 21
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa