Virulence properties of asymptomatic bacteriuria Escherichia coli

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

In asymptomatic bacteriuria (ABU), bacteria colonize the urinary tract without provoking symptoms. Here, we compared the virulence properties of a collection of ABU Escherichia coli strains to cystitis and pyelonephritis strains. Specific urinary tract infection (UTI)-associated virulence genes, hemagglutination characteristics, siderophore production, hemolysis, biofilm formation, and the ability of strains to adhere to and induce cytokine responses in epithelial cells were analyzed. ABU strains were phylogenetically related to strains that cause symptomatic UTI. However, the virulence properties of the ABU strains were variable and dependent on a combination of genotypic and phenotypic factors. Most ABU strains adhered poorly to epithelial cells; however, we also identified a subgroup of strongly adherent strains that were unable to stimulate an epithelial cell IL-6 cytokine response. Poor immune activation may represent one mechanism whereby ABU E coli evade immune detection after the establishment of bacteriuria. (C) 2008 Elsevier GmbH. All rights reserved.

Detaljer

Författare
  • Amanda N. Mabbett
  • Glen C. Ulett
  • Rebecca E. Watts
  • Jai J. Tree
  • Makrina Totsika
  • Cheryl-lynn Y. Ong
  • Jacqueline M. Wood
  • Wayne Monaghan
  • David F. Looke
  • Graeme R. Nimmo
  • Catharina Svanborg
  • Mark A. Schembri
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Mikrobiologi inom det medicinska området

Nyckelord

Originalspråkengelska
Sidor (från-till)53-63
TidskriftInternational Journal of Medical Microbiology
Volym299
Utgivningsnummer1
StatusPublished - 2009
PublikationskategoriForskning
Peer review utfördJa