Visual outcome, endocrine function and tumor control after fractionated stereotactic radiation therapy of craniopharyngiomas in adults: findings in a prospective cohort

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Visual outcome, endocrine function and tumor control after fractionated stereotactic radiation therapy of craniopharyngiomas in adults : findings in a prospective cohort. / Astradsson, Arnar; Munck af Rosenschöld, Per; Feldt-Rasmussen, Ulla; Poulsgaard, Lars; Wiencke, Anne Katrine; Ohlhues, Lars; Engelholm, Svend Aage; Broholm, Helle; Hansen Møller, Emil; Klose, Marianne; Roed, Henrik; Juhler, Marianne.

I: Acta Oncologica, Vol. 56, Nr. 3, 04.03.2017, s. 415-421.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Astradsson, A, Munck af Rosenschöld, P, Feldt-Rasmussen, U, Poulsgaard, L, Wiencke, AK, Ohlhues, L, Engelholm, SA, Broholm, H, Hansen Møller, E, Klose, M, Roed, H & Juhler, M 2017, 'Visual outcome, endocrine function and tumor control after fractionated stereotactic radiation therapy of craniopharyngiomas in adults: findings in a prospective cohort', Acta Oncologica, vol. 56, nr. 3, s. 415-421. https://doi.org/10.1080/0284186X.2016.1270466

APA

Astradsson, A., Munck af Rosenschöld, P., Feldt-Rasmussen, U., Poulsgaard, L., Wiencke, A. K., Ohlhues, L., Engelholm, S. A., Broholm, H., Hansen Møller, E., Klose, M., Roed, H., & Juhler, M. (2017). Visual outcome, endocrine function and tumor control after fractionated stereotactic radiation therapy of craniopharyngiomas in adults: findings in a prospective cohort. Acta Oncologica, 56(3), 415-421. https://doi.org/10.1080/0284186X.2016.1270466

CBE

Astradsson A, Munck af Rosenschöld P, Feldt-Rasmussen U, Poulsgaard L, Wiencke AK, Ohlhues L, Engelholm SA, Broholm H, Hansen Møller E, Klose M, Roed H, Juhler M. 2017. Visual outcome, endocrine function and tumor control after fractionated stereotactic radiation therapy of craniopharyngiomas in adults: findings in a prospective cohort. Acta Oncologica. 56(3):415-421. https://doi.org/10.1080/0284186X.2016.1270466

MLA

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Author

Astradsson, Arnar ; Munck af Rosenschöld, Per ; Feldt-Rasmussen, Ulla ; Poulsgaard, Lars ; Wiencke, Anne Katrine ; Ohlhues, Lars ; Engelholm, Svend Aage ; Broholm, Helle ; Hansen Møller, Emil ; Klose, Marianne ; Roed, Henrik ; Juhler, Marianne. / Visual outcome, endocrine function and tumor control after fractionated stereotactic radiation therapy of craniopharyngiomas in adults : findings in a prospective cohort. I: Acta Oncologica. 2017 ; Vol. 56, Nr. 3. s. 415-421.

RIS

TY - JOUR

T1 - Visual outcome, endocrine function and tumor control after fractionated stereotactic radiation therapy of craniopharyngiomas in adults

T2 - findings in a prospective cohort

AU - Astradsson, Arnar

AU - Munck af Rosenschöld, Per

AU - Feldt-Rasmussen, Ulla

AU - Poulsgaard, Lars

AU - Wiencke, Anne Katrine

AU - Ohlhues, Lars

AU - Engelholm, Svend Aage

AU - Broholm, Helle

AU - Hansen Møller, Emil

AU - Klose, Marianne

AU - Roed, Henrik

AU - Juhler, Marianne

PY - 2017/3/4

Y1 - 2017/3/4

N2 - Background: The purpose of this study was to examine visual outcome, endocrine function and tumor control in a prospective cohort of craniopharyngioma patients, treated with fractionated stereotactic radiation therapy (FSRT). Material and methods: Sixteen adult patients with craniopharyngiomas were eligible for analysis. They were treated with linear accelerator-based FSRT during 1999–2015. In all cases, diagnosis was confirmed by histological analysis. The prescription dose to the tumor was 54 Gy (median, range 48–54) in 1.8 or 2.0 Gy per fraction, and the maximum radiation dose to the optic nerves and chiasm was 54.2 Gy (median, range 48.6–60.0) for the cohort. Serial ophthalmological and endocrine evaluations and magnetic resonance imaging (MRI) scans were performed at regular intervals. Median follow-up was 3.3 years (range 1.1–14.1), 3.7 years (range 0.8–15.2), and 3.6 years (range 0.7–13.1) for visual outcome, endocrine function, and tumor control, respectively. Results: Visual acuity impairment was present in 10 patients (62.5%) and visual field defects were present in 12 patients (75%) before FSRT. One patient developed radiation-induced optic neuropathy at seven years after FSRT. Thirteen of 16 patients (81.3%) had pituitary deficiency before FSRT, and did not develop further pituitary deficiency after FSRT. Mean tumor volume pre-FSRT was 2.72 cm3 (range 0.20–9.90) and post-FSRT 1.2 cm3 (range 0.00–13.10). Tumor control rate was 81.3% at two, five, and 10 years after FSRT. Conclusions: FSRT was relatively safe in this prospective cohort of craniopharyngiomas, with only one case of radiation-induced optic neuropathy and no case of new endocrinopathy. Tumor control rate was acceptable.

AB - Background: The purpose of this study was to examine visual outcome, endocrine function and tumor control in a prospective cohort of craniopharyngioma patients, treated with fractionated stereotactic radiation therapy (FSRT). Material and methods: Sixteen adult patients with craniopharyngiomas were eligible for analysis. They were treated with linear accelerator-based FSRT during 1999–2015. In all cases, diagnosis was confirmed by histological analysis. The prescription dose to the tumor was 54 Gy (median, range 48–54) in 1.8 or 2.0 Gy per fraction, and the maximum radiation dose to the optic nerves and chiasm was 54.2 Gy (median, range 48.6–60.0) for the cohort. Serial ophthalmological and endocrine evaluations and magnetic resonance imaging (MRI) scans were performed at regular intervals. Median follow-up was 3.3 years (range 1.1–14.1), 3.7 years (range 0.8–15.2), and 3.6 years (range 0.7–13.1) for visual outcome, endocrine function, and tumor control, respectively. Results: Visual acuity impairment was present in 10 patients (62.5%) and visual field defects were present in 12 patients (75%) before FSRT. One patient developed radiation-induced optic neuropathy at seven years after FSRT. Thirteen of 16 patients (81.3%) had pituitary deficiency before FSRT, and did not develop further pituitary deficiency after FSRT. Mean tumor volume pre-FSRT was 2.72 cm3 (range 0.20–9.90) and post-FSRT 1.2 cm3 (range 0.00–13.10). Tumor control rate was 81.3% at two, five, and 10 years after FSRT. Conclusions: FSRT was relatively safe in this prospective cohort of craniopharyngiomas, with only one case of radiation-induced optic neuropathy and no case of new endocrinopathy. Tumor control rate was acceptable.

UR - http://www.scopus.com/inward/record.url?scp=85010666401&partnerID=8YFLogxK

U2 - 10.1080/0284186X.2016.1270466

DO - 10.1080/0284186X.2016.1270466

M3 - Article

C2 - 28084862

AN - SCOPUS:85010666401

VL - 56

SP - 415

EP - 421

JO - Acta Oncologica

JF - Acta Oncologica

SN - 1651-226X

IS - 3

ER -