Vital capacity and COPD: The Swedish CArdioPulmonary bioImage Study (SCAPIS)

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift


Background: Spirometric diagnosis of chronic obstructive pulmonary disease (COPD) is based on the ratio of forced expiratory volume in 1 second (FEV1)/vital capacity (VC), either as a fixed value 1/VC ratio in a general population setting. The second aim was to evaluate the characteristics of subjects with COPD who obtained a higher SVC than FVC. Methods: Subjects (n=1,050) aged 50-64 years were investigated with FEV1, FVC, and SVC after bronchodilation. Global Initiative for Chronic Obstructive Lung Disease (GOLD) COPDFVC was defined as FEV1/FVC VC as FEV1/VC FVC as FEV1/FVC below the LLN, and LLNCOPDVC as FEV1/VC below the LLN using the maximum value of FVC or SVC. Results: Prevalence of GOLDCOPDFVC was 10.0% (95% confidence interval [CI] 8.2-12.0) and the prevalence of LLNCOPDFVC was 9.5% (95% CI 7.8-11.4). When estimates were based on VC, the prevalence became higher; 16.4% (95% CI 14.3-18.9) and 15.6% (95% CI 13.5-17.9) for GOLDCOPDVC and LLNCOPDVC, respectively. The group of additional subjects classified as having COPD based on VC, had lower FEV1, more wheeze and higher residual volume compared to subjects without any COPD. Conclusion: The prevalence of COPD was significantly higher when the ratio FEV1/VC was calculated using the highest value of SVC or FVC compared with using FVC only. Subjects classified as having COPD when using the VC concept were more obstructive and with indications of air trapping. Hence, the use of only FVC when assessing airflow limitation may result in a considerable under diagnosis of subjects with mild COPD.


  • Kjell Torén
  • Anna Carin Olin
  • Anne Lindberg
  • Jenny Vikgren
  • Linus Schiöler
  • John Brandberg
  • Åse Johnsson
  • Gunnar Engström
  • H. Lennart Persson
  • Magnus Sköld
  • Jan Hedner
  • Eva Lindberg
  • Andrei Malinovschi
  • Eeva Piitulainen
  • Per Wollmer
  • Annika Rosengren
  • Christer Janson
  • Anders Blomberg
  • Göran Bergström
Enheter & grupper
Externa organisationer
  • Göteborgs universitet
  • Umeå University
  • Linköping University
  • Karolinska Institute
  • Uppsala universitet

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Lungmedicin och allergi


Sidor (från-till)927-933
Antal sidor7
TidskriftThe International Journal of Chronic Obstructive Pulmonary Disease
Utgåva nummer1
StatusPublished - 2016 maj 2
Peer review utfördJa