Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

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title = "Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort",
abstract = "Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. We also evaluated the association between these polymorphisms and baseline plasma vitamin C levels in a subset of participants. Four SNPs were predictors of plasma vitamin C levels (SLC23A1 rs11950646 and rs33972313; SLC23A2 rs6053005 and rs6133175) in multivariable linear regression models. One SNP (SLC23A2 rs6116569) was associated with GC risk, in particular non-cardia GC (OR = 1.63, 95 % CI = 1.11-2.39, based on 178 non-cardia cases), but this association was attenuated when plasma vitamin C was included in the logistic regression model. Haplotype analysis of SLC23A1 yielded no associations with GC. In SLC23A2, one haplotype was associated with both overall and non-cardia GC, another haplotype was associated with GC overall, and a third was associated with intestinal-type GC. Common variants in SLC23A1 and SLC23A2 may influence plasma vitamin C concentration independent of dietary intake, and variation in SLC23A2 may influence GC risk. Additional prospective studies in large populations and consortia are recommended. Investigation of variation in vitamin C transporter genes may shed light on the preventative properties of vitamin C in gastric carcinogenesis.",
keywords = "Gastric cancer, Vitamin C, Antioxidants, Genetic susceptibility, SLC23A1, SLC23A2",
author = "Duell, {Eric J.} and Leila Lujan-Barroso and Claudia Llivina and Xavier Munoz and Mazda Jenab and Marie-Christine Boutron-Ruault and Francoise Clavel-Chapelon and Antoine Racine and Heiner Boeing and Brian Buijsse and Federico Canzian and Theron Johnson and Christine Dalgard and Kim Overvad and Anne Tjonneland and Anja Olsen and Sanchez, {Soledad C.} and Emilio Sanchez-Cantalejo and Jose-Maria Huerta and Eva Ardanaz and Miren Dorronsoro and Kay-Tee Khaw and Travis, {Ruth C.} and Antonia Trichopoulou and Dimitrios Trichopoulos and Snorri Rafnsson and Domenico Palli and Carlotta Sacerdote and Rosario Tumino and Salvatore Panico and Sara Grioni and Bueno-de-Mesquita, {H. Bas} and Ros, {Martine M.} and Numans, {Mattijs E.} and Peeters, {Petra H.} and Dorthe Johansen and Bjorn Lindkvist and Mattias Johansson and Ingegerd Johansson and Guri Skeie and Elisabete Weiderpass and Talita Duarte-Salles and Roger Stenling and Elio Riboli and Nuria Sala and Gonzalez, {Carlos A.}",
note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)",
year = "2013",
doi = "10.1007/s12263-013-0346-6",
language = "English",
volume = "8",
pages = "549--560",
journal = "Genes and Nutrition",
issn = "1555-8932",
publisher = "New Century Health Publishers",
number = "6",