Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

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Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort. / Duell, Eric J.; Lujan-Barroso, Leila; Llivina, Claudia; Munoz, Xavier; Jenab, Mazda; Boutron-Ruault, Marie-Christine; Clavel-Chapelon, Francoise; Racine, Antoine; Boeing, Heiner; Buijsse, Brian; Canzian, Federico; Johnson, Theron; Dalgard, Christine; Overvad, Kim; Tjonneland, Anne; Olsen, Anja; Sanchez, Soledad C.; Sanchez-Cantalejo, Emilio; Huerta, Jose-Maria; Ardanaz, Eva; Dorronsoro, Miren; Khaw, Kay-Tee; Travis, Ruth C.; Trichopoulou, Antonia; Trichopoulos, Dimitrios; Rafnsson, Snorri; Palli, Domenico; Sacerdote, Carlotta; Tumino, Rosario; Panico, Salvatore; Grioni, Sara; Bueno-de-Mesquita, H. Bas; Ros, Martine M.; Numans, Mattijs E.; Peeters, Petra H.; Johansen, Dorthe; Lindkvist, Bjorn; Johansson, Mattias; Johansson, Ingegerd; Skeie, Guri; Weiderpass, Elisabete; Duarte-Salles, Talita; Stenling, Roger; Riboli, Elio; Sala, Nuria; Gonzalez, Carlos A.

I: Genes & Nutrition, Vol. 8, Nr. 6, 2013, s. 549-560.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Duell, EJ, Lujan-Barroso, L, Llivina, C, Munoz, X, Jenab, M, Boutron-Ruault, M-C, Clavel-Chapelon, F, Racine, A, Boeing, H, Buijsse, B, Canzian, F, Johnson, T, Dalgard, C, Overvad, K, Tjonneland, A, Olsen, A, Sanchez, SC, Sanchez-Cantalejo, E, Huerta, J-M, Ardanaz, E, Dorronsoro, M, Khaw, K-T, Travis, RC, Trichopoulou, A, Trichopoulos, D, Rafnsson, S, Palli, D, Sacerdote, C, Tumino, R, Panico, S, Grioni, S, Bueno-de-Mesquita, HB, Ros, MM, Numans, ME, Peeters, PH, Johansen, D, Lindkvist, B, Johansson, M, Johansson, I, Skeie, G, Weiderpass, E, Duarte-Salles, T, Stenling, R, Riboli, E, Sala, N & Gonzalez, CA 2013, 'Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort', Genes & Nutrition, vol. 8, nr. 6, s. 549-560. https://doi.org/10.1007/s12263-013-0346-6

APA

Duell, E. J., Lujan-Barroso, L., Llivina, C., Munoz, X., Jenab, M., Boutron-Ruault, M-C., Clavel-Chapelon, F., Racine, A., Boeing, H., Buijsse, B., Canzian, F., Johnson, T., Dalgard, C., Overvad, K., Tjonneland, A., Olsen, A., Sanchez, S. C., Sanchez-Cantalejo, E., Huerta, J-M., ... Gonzalez, C. A. (2013). Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort. Genes & Nutrition, 8(6), 549-560. https://doi.org/10.1007/s12263-013-0346-6

CBE

Duell EJ, Lujan-Barroso L, Llivina C, Munoz X, Jenab M, Boutron-Ruault M-C, Clavel-Chapelon F, Racine A, Boeing H, Buijsse B, Canzian F, Johnson T, Dalgard C, Overvad K, Tjonneland A, Olsen A, Sanchez SC, Sanchez-Cantalejo E, Huerta J-M, Ardanaz E, Dorronsoro M, Khaw K-T, Travis RC, Trichopoulou A, Trichopoulos D, Rafnsson S, Palli D, Sacerdote C, Tumino R, Panico S, Grioni S, Bueno-de-Mesquita HB, Ros MM, Numans ME, Peeters PH, Johansen D, Lindkvist B, Johansson M, Johansson I, Skeie G, Weiderpass E, Duarte-Salles T, Stenling R, Riboli E, Sala N, Gonzalez CA. 2013. Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort. Genes & Nutrition. 8(6):549-560. https://doi.org/10.1007/s12263-013-0346-6

MLA

Vancouver

Author

Duell, Eric J. ; Lujan-Barroso, Leila ; Llivina, Claudia ; Munoz, Xavier ; Jenab, Mazda ; Boutron-Ruault, Marie-Christine ; Clavel-Chapelon, Francoise ; Racine, Antoine ; Boeing, Heiner ; Buijsse, Brian ; Canzian, Federico ; Johnson, Theron ; Dalgard, Christine ; Overvad, Kim ; Tjonneland, Anne ; Olsen, Anja ; Sanchez, Soledad C. ; Sanchez-Cantalejo, Emilio ; Huerta, Jose-Maria ; Ardanaz, Eva ; Dorronsoro, Miren ; Khaw, Kay-Tee ; Travis, Ruth C. ; Trichopoulou, Antonia ; Trichopoulos, Dimitrios ; Rafnsson, Snorri ; Palli, Domenico ; Sacerdote, Carlotta ; Tumino, Rosario ; Panico, Salvatore ; Grioni, Sara ; Bueno-de-Mesquita, H. Bas ; Ros, Martine M. ; Numans, Mattijs E. ; Peeters, Petra H. ; Johansen, Dorthe ; Lindkvist, Bjorn ; Johansson, Mattias ; Johansson, Ingegerd ; Skeie, Guri ; Weiderpass, Elisabete ; Duarte-Salles, Talita ; Stenling, Roger ; Riboli, Elio ; Sala, Nuria ; Gonzalez, Carlos A. / Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort. I: Genes & Nutrition. 2013 ; Vol. 8, Nr. 6. s. 549-560.

RIS

TY - JOUR

T1 - Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

AU - Duell, Eric J.

AU - Lujan-Barroso, Leila

AU - Llivina, Claudia

AU - Munoz, Xavier

AU - Jenab, Mazda

AU - Boutron-Ruault, Marie-Christine

AU - Clavel-Chapelon, Francoise

AU - Racine, Antoine

AU - Boeing, Heiner

AU - Buijsse, Brian

AU - Canzian, Federico

AU - Johnson, Theron

AU - Dalgard, Christine

AU - Overvad, Kim

AU - Tjonneland, Anne

AU - Olsen, Anja

AU - Sanchez, Soledad C.

AU - Sanchez-Cantalejo, Emilio

AU - Huerta, Jose-Maria

AU - Ardanaz, Eva

AU - Dorronsoro, Miren

AU - Khaw, Kay-Tee

AU - Travis, Ruth C.

AU - Trichopoulou, Antonia

AU - Trichopoulos, Dimitrios

AU - Rafnsson, Snorri

AU - Palli, Domenico

AU - Sacerdote, Carlotta

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Grioni, Sara

AU - Bueno-de-Mesquita, H. Bas

AU - Ros, Martine M.

AU - Numans, Mattijs E.

AU - Peeters, Petra H.

AU - Johansen, Dorthe

AU - Lindkvist, Bjorn

AU - Johansson, Mattias

AU - Johansson, Ingegerd

AU - Skeie, Guri

AU - Weiderpass, Elisabete

AU - Duarte-Salles, Talita

AU - Stenling, Roger

AU - Riboli, Elio

AU - Sala, Nuria

AU - Gonzalez, Carlos A.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

PY - 2013

Y1 - 2013

N2 - Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. We also evaluated the association between these polymorphisms and baseline plasma vitamin C levels in a subset of participants. Four SNPs were predictors of plasma vitamin C levels (SLC23A1 rs11950646 and rs33972313; SLC23A2 rs6053005 and rs6133175) in multivariable linear regression models. One SNP (SLC23A2 rs6116569) was associated with GC risk, in particular non-cardia GC (OR = 1.63, 95 % CI = 1.11-2.39, based on 178 non-cardia cases), but this association was attenuated when plasma vitamin C was included in the logistic regression model. Haplotype analysis of SLC23A1 yielded no associations with GC. In SLC23A2, one haplotype was associated with both overall and non-cardia GC, another haplotype was associated with GC overall, and a third was associated with intestinal-type GC. Common variants in SLC23A1 and SLC23A2 may influence plasma vitamin C concentration independent of dietary intake, and variation in SLC23A2 may influence GC risk. Additional prospective studies in large populations and consortia are recommended. Investigation of variation in vitamin C transporter genes may shed light on the preventative properties of vitamin C in gastric carcinogenesis.

AB - Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. We also evaluated the association between these polymorphisms and baseline plasma vitamin C levels in a subset of participants. Four SNPs were predictors of plasma vitamin C levels (SLC23A1 rs11950646 and rs33972313; SLC23A2 rs6053005 and rs6133175) in multivariable linear regression models. One SNP (SLC23A2 rs6116569) was associated with GC risk, in particular non-cardia GC (OR = 1.63, 95 % CI = 1.11-2.39, based on 178 non-cardia cases), but this association was attenuated when plasma vitamin C was included in the logistic regression model. Haplotype analysis of SLC23A1 yielded no associations with GC. In SLC23A2, one haplotype was associated with both overall and non-cardia GC, another haplotype was associated with GC overall, and a third was associated with intestinal-type GC. Common variants in SLC23A1 and SLC23A2 may influence plasma vitamin C concentration independent of dietary intake, and variation in SLC23A2 may influence GC risk. Additional prospective studies in large populations and consortia are recommended. Investigation of variation in vitamin C transporter genes may shed light on the preventative properties of vitamin C in gastric carcinogenesis.

KW - Gastric cancer

KW - Vitamin C

KW - Antioxidants

KW - Genetic susceptibility

KW - SLC23A1

KW - SLC23A2

U2 - 10.1007/s12263-013-0346-6

DO - 10.1007/s12263-013-0346-6

M3 - Article

C2 - 23737080

VL - 8

SP - 549

EP - 560

JO - Genes and Nutrition

JF - Genes and Nutrition

SN - 1555-8932

IS - 6

ER -