Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men

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Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men. / Lee, David M.; Rutter, Martin K.; O'Neill, Terrence W.; Boonen, Steven; Vandershueren, Dirk; Bouillon, Roger; Bartfai, Gyorgy; Casanueva, Felipe F.; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Huhtamemi, Ilpo T.; Kula, Krzysztof; Lean, Micheal E. J.; Pendleton, Neil; Punab, Margus; Silman, Alan J.; Hu, Frederick C. W.

I: European Journal of Endocrinology, Vol. 161, Nr. 6, 2009, s. 947-954.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Lee, DM, Rutter, MK, O'Neill, TW, Boonen, S, Vandershueren, D, Bouillon, R, Bartfai, G, Casanueva, FF, Finn, JD, Forti, G, Giwercman, A, Han, TS, Huhtamemi, IT, Kula, K, Lean, MEJ, Pendleton, N, Punab, M, Silman, AJ & Hu, FCW 2009, 'Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men', European Journal of Endocrinology, vol. 161, nr. 6, s. 947-954. https://doi.org/10.1530/EJE-09-0496

APA

Lee, D. M., Rutter, M. K., O'Neill, T. W., Boonen, S., Vandershueren, D., Bouillon, R., ... Hu, F. C. W. (2009). Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men. European Journal of Endocrinology, 161(6), 947-954. https://doi.org/10.1530/EJE-09-0496

CBE

Lee DM, Rutter MK, O'Neill TW, Boonen S, Vandershueren D, Bouillon R, Bartfai G, Casanueva FF, Finn JD, Forti G, Giwercman A, Han TS, Huhtamemi IT, Kula K, Lean MEJ, Pendleton N, Punab M, Silman AJ, Hu FCW. 2009. Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men. European Journal of Endocrinology. 161(6):947-954. https://doi.org/10.1530/EJE-09-0496

MLA

Vancouver

Author

Lee, David M. ; Rutter, Martin K. ; O'Neill, Terrence W. ; Boonen, Steven ; Vandershueren, Dirk ; Bouillon, Roger ; Bartfai, Gyorgy ; Casanueva, Felipe F. ; Finn, Joseph D. ; Forti, Gianni ; Giwercman, Aleksander ; Han, Thang S. ; Huhtamemi, Ilpo T. ; Kula, Krzysztof ; Lean, Micheal E. J. ; Pendleton, Neil ; Punab, Margus ; Silman, Alan J. ; Hu, Frederick C. W. / Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men. I: European Journal of Endocrinology. 2009 ; Vol. 161, Nr. 6. s. 947-954.

RIS

TY - JOUR

T1 - Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men

AU - Lee, David M.

AU - Rutter, Martin K.

AU - O'Neill, Terrence W.

AU - Boonen, Steven

AU - Vandershueren, Dirk

AU - Bouillon, Roger

AU - Bartfai, Gyorgy

AU - Casanueva, Felipe F.

AU - Finn, Joseph D.

AU - Forti, Gianni

AU - Giwercman, Aleksander

AU - Han, Thang S.

AU - Huhtamemi, Ilpo T.

AU - Kula, Krzysztof

AU - Lean, Micheal E. J.

AU - Pendleton, Neil

AU - Punab, Margus

AU - Silman, Alan J.

AU - Hu, Frederick C. W.

PY - 2009

Y1 - 2009

N2 - Objectives: Low serum 25-hydroxyviatmin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked to insulin resistance, the metabolic syndrome (MetS) and its components. Data in healthy, community-dwelling Europeans are lacking, and previous studies have not excluded subjects receiving drug treatments that may distort the relationship between 25(OH)D/PTH and MetS. The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men Design: This was a population-based, cross-sectional study of 3369 men aged 40-79 years enrolled in the European Male Ageing Study. Results After exclusion of subjects with missing data. 3069 men with a mean (+/- S.D.) age of 60 +/- 11 years were included in the analysis. Age-adjusted 25(OH)D levels were inversely associated with waist circumference, systolic blood pressure (BP), triglycerides, and glucose (all P < 0.01) Age-adjusted PTH levels were only associated with waist and diastolic BP (both P < 0.05). After adjusting for age, centre, season and lifestyle factors the odds for MetS decreased across increasing 25(OH)D quintiles (odds ratios 0.48 (95% confidence intervals 0.36-0.64) highest versus lowest quintile. P-trend < 0.001). This relationship was unchanged after adjustment for PTH, but was attenuated after additional adjustment for homeostasis model assessment of insulin resistance (0.60 (0.47-0.78) P-trend < 0.001) There was no association between PTH and MetS. Conclusions: Our results demonstrate an inverse relationship between 25(OH)D levels and MetS, which is independent of several confounders and PTH. The relationship is partly explained by insulin resistance. The clinical significance of these observations warrants further study

AB - Objectives: Low serum 25-hydroxyviatmin D (25(OH)D) and elevated parathyroid hormone (PTH) levels have been linked to insulin resistance, the metabolic syndrome (MetS) and its components. Data in healthy, community-dwelling Europeans are lacking, and previous studies have not excluded subjects receiving drug treatments that may distort the relationship between 25(OH)D/PTH and MetS. The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men Design: This was a population-based, cross-sectional study of 3369 men aged 40-79 years enrolled in the European Male Ageing Study. Results After exclusion of subjects with missing data. 3069 men with a mean (+/- S.D.) age of 60 +/- 11 years were included in the analysis. Age-adjusted 25(OH)D levels were inversely associated with waist circumference, systolic blood pressure (BP), triglycerides, and glucose (all P < 0.01) Age-adjusted PTH levels were only associated with waist and diastolic BP (both P < 0.05). After adjusting for age, centre, season and lifestyle factors the odds for MetS decreased across increasing 25(OH)D quintiles (odds ratios 0.48 (95% confidence intervals 0.36-0.64) highest versus lowest quintile. P-trend < 0.001). This relationship was unchanged after adjustment for PTH, but was attenuated after additional adjustment for homeostasis model assessment of insulin resistance (0.60 (0.47-0.78) P-trend < 0.001) There was no association between PTH and MetS. Conclusions: Our results demonstrate an inverse relationship between 25(OH)D levels and MetS, which is independent of several confounders and PTH. The relationship is partly explained by insulin resistance. The clinical significance of these observations warrants further study

U2 - 10.1530/EJE-09-0496

DO - 10.1530/EJE-09-0496

M3 - Article

VL - 161

SP - 947

EP - 954

JO - European Journal of Endocrinology

T2 - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 1479-683X

IS - 6

ER -