Watching DNA condensation induced by poly(amido amine) dendrimers with time-resolved cryo-TEM.

Forskningsoutput: TidskriftsbidragLetter

Abstract

The condensation of DNA by poly(amido amine) dendrimers of generation 1, 2, and 4 has been followed by time-resolved cryogenic transmission electron microscopy (cryo-TEM). The recorded images show that significant morphological rearrangement occurs for DNA condensed with the lower generation dendrimers leading to the formation of toroidal aggregates. Higher charge density dendrimers, on the other hand, give rise to globular aggregates, where no transient morphologies are observed. We suggest that the dendrimers in this case are kinetically trapped as soon as they bind to the DNA strand.

Detaljer

Författare
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Fysikalisk kemi
Originalspråkengelska
Sidor (från-till)12466-12470
TidskriftLangmuir
Volym25
Utgåva nummer21
StatusPublished - 2009
PublikationskategoriForskning
Peer review utfördJa