Weight loss and body mass index in relation to aspiration in patients treated for head and neck cancer: a long-term follow-up

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Weight loss and body mass index in relation to aspiration in patients treated for head and neck cancer: a long-term follow-up. / Ottosson, Sandra; Lindblom, Ulrika; Wahlberg, Peter; Nilsson, Per; Kjellén, Elisabeth; Zackrisson, Bjorn; Jaghagen, Eva Levring; Laurell, Goran.

I: Supportive Care in Cancer, Vol. 22, Nr. 9, 2014, s. 2361-2369.

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Ottosson, Sandra ; Lindblom, Ulrika ; Wahlberg, Peter ; Nilsson, Per ; Kjellén, Elisabeth ; Zackrisson, Bjorn ; Jaghagen, Eva Levring ; Laurell, Goran. / Weight loss and body mass index in relation to aspiration in patients treated for head and neck cancer: a long-term follow-up. I: Supportive Care in Cancer. 2014 ; Vol. 22, Nr. 9. s. 2361-2369.

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TY - JOUR

T1 - Weight loss and body mass index in relation to aspiration in patients treated for head and neck cancer: a long-term follow-up

AU - Ottosson, Sandra

AU - Lindblom, Ulrika

AU - Wahlberg, Peter

AU - Nilsson, Per

AU - Kjellén, Elisabeth

AU - Zackrisson, Bjorn

AU - Jaghagen, Eva Levring

AU - Laurell, Goran

PY - 2014

Y1 - 2014

N2 - Persistent severe swallowing dysfunction with aspiration is a common and sometimes overlooked sequelae after treatment for squamous cell carcinoma of the head and neck (SCCHN) and may impact food intake and nutritional status. More knowledge is needed to increase the understanding of severe swallowing dysfunction as a risk factor for persistent nutritional deteriorations in SCCHN survivors. The purpose of the study was to investigate weight loss and body mass index (BMI) in relation to pharyngeal swallowing function in a long-term perspective in patients after SCCHN treatment. Data from 101 patients were available for the analyses. Swallowing function was assessed by videofluoroscopy at a mean of 71.6 months after the start of radiotherapy (RT). Percent weight change (calculated with weight at the start of RT as the reference) and BMI at follow-up were the primary nutritional measures. Aspiration was present in 48 of 101 patients (48 %). Patients with aspiration had a significantly higher mean weight loss and a lower BMI (-10.9 % and 23.1, respectively) at follow-up compared with patients without aspiration (-2.8 % and 26.0, respectively). Patients with aspiration were unable to gain weight after 23 months. Only ten of 101 patients (10 %) were underweight at follow-up. Swallowing dysfunction with aspiration was related to long-term weight loss and reduced BMI. Few patients were underweight despite the high prevalence of swallowing dysfunction.

AB - Persistent severe swallowing dysfunction with aspiration is a common and sometimes overlooked sequelae after treatment for squamous cell carcinoma of the head and neck (SCCHN) and may impact food intake and nutritional status. More knowledge is needed to increase the understanding of severe swallowing dysfunction as a risk factor for persistent nutritional deteriorations in SCCHN survivors. The purpose of the study was to investigate weight loss and body mass index (BMI) in relation to pharyngeal swallowing function in a long-term perspective in patients after SCCHN treatment. Data from 101 patients were available for the analyses. Swallowing function was assessed by videofluoroscopy at a mean of 71.6 months after the start of radiotherapy (RT). Percent weight change (calculated with weight at the start of RT as the reference) and BMI at follow-up were the primary nutritional measures. Aspiration was present in 48 of 101 patients (48 %). Patients with aspiration had a significantly higher mean weight loss and a lower BMI (-10.9 % and 23.1, respectively) at follow-up compared with patients without aspiration (-2.8 % and 26.0, respectively). Patients with aspiration were unable to gain weight after 23 months. Only ten of 101 patients (10 %) were underweight at follow-up. Swallowing dysfunction with aspiration was related to long-term weight loss and reduced BMI. Few patients were underweight despite the high prevalence of swallowing dysfunction.

KW - Fluoroscopy

KW - Swallowing dysfunction

KW - Head and neck cancer

KW - Weight loss

KW - Body mass index

U2 - 10.1007/s00520-014-2211-6

DO - 10.1007/s00520-014-2211-6

M3 - Article

C2 - 24687537

VL - 22

SP - 2361

EP - 2369

JO - Supportive Care in Cancer

JF - Supportive Care in Cancer

SN - 0941-4355

IS - 9

ER -