Weight loss in Huntington disease increases with higher CAG repeat number

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Weight loss in Huntington disease increases with higher CAG repeat number. / Aziz, N. A.; van der Burg, Jorien m; Landwehrmeyer, G. B.; Brundin, Patrik; Stijnen, T.; Roos, R. A. C.

I: Neurology, Vol. 71, Nr. 19, 2008, s. 1506-1513.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Aziz, NA, van der Burg, JM, Landwehrmeyer, GB, Brundin, P, Stijnen, T & Roos, RAC 2008, 'Weight loss in Huntington disease increases with higher CAG repeat number', Neurology, vol. 71, nr. 19, s. 1506-1513. https://doi.org/10.1212/01.wnl.0000334276.09729.0e

APA

Aziz, N. A., van der Burg, J. M., Landwehrmeyer, G. B., Brundin, P., Stijnen, T., & Roos, R. A. C. (2008). Weight loss in Huntington disease increases with higher CAG repeat number. Neurology, 71(19), 1506-1513. https://doi.org/10.1212/01.wnl.0000334276.09729.0e

CBE

Aziz NA, van der Burg JM, Landwehrmeyer GB, Brundin P, Stijnen T, Roos RAC. 2008. Weight loss in Huntington disease increases with higher CAG repeat number. Neurology. 71(19):1506-1513. https://doi.org/10.1212/01.wnl.0000334276.09729.0e

MLA

Vancouver

Aziz NA, van der Burg JM, Landwehrmeyer GB, Brundin P, Stijnen T, Roos RAC. Weight loss in Huntington disease increases with higher CAG repeat number. Neurology. 2008;71(19):1506-1513. https://doi.org/10.1212/01.wnl.0000334276.09729.0e

Author

Aziz, N. A. ; van der Burg, Jorien m ; Landwehrmeyer, G. B. ; Brundin, Patrik ; Stijnen, T. ; Roos, R. A. C. / Weight loss in Huntington disease increases with higher CAG repeat number. I: Neurology. 2008 ; Vol. 71, Nr. 19. s. 1506-1513.

RIS

TY - JOUR

T1 - Weight loss in Huntington disease increases with higher CAG repeat number

AU - Aziz, N. A.

AU - van der Burg, Jorien m

AU - Landwehrmeyer, G. B.

AU - Brundin, Patrik

AU - Stijnen, T.

AU - Roos, R. A. C.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)

PY - 2008

Y1 - 2008

N2 - Objective: Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded number of CAG repeats in the huntingtin gene. A hallmark of HD is unintended weight loss, the cause of which is unknown. In order to elucidate the underlying mechanisms of weight loss in HD, we studied its relation to other disease characteristics including motor, cognitive, and behavioral disturbances and CAG repeat number. Methods: In 517 patients with early stage HD, we applied mixed-effects model analyses to correlate weight changes over 3 years to CAG repeat number and various components of the Unified Huntington's Disease Rating Scale (UHDRS). We also assessed the relation between CAG repeat number and body weight and caloric intake in the R6/2 mouse model of HD. Results: In patients with HD, mean body mass index decreased with -0.15 units per year (p < 0.001). However, no single UHDRS component, including motor, cognitive, and behavioral scores, was independently associated with the rate of weight loss. Patients with HD with a higher CAG repeat number had a faster rate of weight loss. Similarly, R6/2 mice with a larger CAG repeat length had a lower body weight, whereas caloric intake increased with larger CAG repeat length. Conclusions: Weight loss in Huntington disease (HD) is directly linked to CAG repeat length and is likely to result from a hypermetabolic state. Other signs and symptoms of HD are unlikely to contribute to weight loss in early disease stages. Elucidation of the responsible mechanisms could lead to effective energy-based therapeutics. Neurology (R) 2008;71:1506-1513

AB - Objective: Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded number of CAG repeats in the huntingtin gene. A hallmark of HD is unintended weight loss, the cause of which is unknown. In order to elucidate the underlying mechanisms of weight loss in HD, we studied its relation to other disease characteristics including motor, cognitive, and behavioral disturbances and CAG repeat number. Methods: In 517 patients with early stage HD, we applied mixed-effects model analyses to correlate weight changes over 3 years to CAG repeat number and various components of the Unified Huntington's Disease Rating Scale (UHDRS). We also assessed the relation between CAG repeat number and body weight and caloric intake in the R6/2 mouse model of HD. Results: In patients with HD, mean body mass index decreased with -0.15 units per year (p < 0.001). However, no single UHDRS component, including motor, cognitive, and behavioral scores, was independently associated with the rate of weight loss. Patients with HD with a higher CAG repeat number had a faster rate of weight loss. Similarly, R6/2 mice with a larger CAG repeat length had a lower body weight, whereas caloric intake increased with larger CAG repeat length. Conclusions: Weight loss in Huntington disease (HD) is directly linked to CAG repeat length and is likely to result from a hypermetabolic state. Other signs and symptoms of HD are unlikely to contribute to weight loss in early disease stages. Elucidation of the responsible mechanisms could lead to effective energy-based therapeutics. Neurology (R) 2008;71:1506-1513

U2 - 10.1212/01.wnl.0000334276.09729.0e

DO - 10.1212/01.wnl.0000334276.09729.0e

M3 - Article

C2 - 18981372

VL - 71

SP - 1506

EP - 1513

JO - Neurology

JF - Neurology

SN - 1526-632X

IS - 19

ER -