What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?

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What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease? / Dunning, Christopher; George, Sonia; Brundin, Patrik.

I: Prion, Vol. 7, Nr. 1, 2013, s. 92-97.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Dunning, Christopher ; George, Sonia ; Brundin, Patrik. / What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?. I: Prion. 2013 ; Vol. 7, Nr. 1. s. 92-97.

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TY - JOUR

T1 - What's to like about the prion-like hypothesis for the spreading of aggregated α-synuclein in Parkinson disease?

AU - Dunning, Christopher

AU - George, Sonia

AU - Brundin, Patrik

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041)

PY - 2013

Y1 - 2013

N2 - α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease. Misfolded α-synuclein has also been shown to spread from cell-to-cell and, in a prion-like fashion, trigger aggregation of α-synuclein in the recipient cell. In this mini-review we explore the evidence that misfolded α-synuclein underlies the spread of pathology in Parkinson disease and discuss why it should be considered a prion-like protein.

AB - α-Synuclein is a key protein in Parkinson disease. Not only is it the major protein component of Lewy bodies, but it is implicated in several cellular processes that are disrupted in Parkinson disease. Misfolded α-synuclein has also been shown to spread from cell-to-cell and, in a prion-like fashion, trigger aggregation of α-synuclein in the recipient cell. In this mini-review we explore the evidence that misfolded α-synuclein underlies the spread of pathology in Parkinson disease and discuss why it should be considered a prion-like protein.

KW - protein misfolding

KW - cell-to-cell transfer

KW - Parkinson disease

KW - alpha-synuclein

KW - prion-like

U2 - 10.4161/pri.23806

DO - 10.4161/pri.23806

M3 - Article

VL - 7

SP - 92

EP - 97

JO - Prion

JF - Prion

SN - 1933-6896

IS - 1

ER -