Which acne treatment has the best influence on health-related quality of life? Literature review by the European Academy of Dermatology and Venereology Task Force on Quality of Life and Patient Oriented Outcomes

Forskningsoutput: TidskriftsbidragÖversiktsartikel

Abstract

According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS), most of the publications where health-related (HR) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO decided to detect which acne treatment has the best influence on HRQoL of acne patients. A new literature search was organized to find publications on acne treatment where the HRQoL of patients was assessed as an outcome measure. From 186 papers with HRQoL assessment, 37 papers were included for further analysis. Our results revealed that oral isotretinoin had the best influence on HRQoL of acne patients. Several other treatment methods also showed good effects on the HRQoL of acne patients. Oral isotretinoin and norethindrone acetate/ethinyl estradiol, topical clindamycin phosphate/benzoyl peroxide and adapalene/benzoyl peroxide showed significantly better effect on HRQoL than placebo. There is limited number of the high-quality studies on acne treatment where HRQoL was assessed. Dermatology-specific and acne-specific instruments showed much better sensitivity to successful therapeutic intervention than generic HRQoL instruments. The most frequently used HRQoL instrument was the Dermatology Life Quality Index questionnaire.

Detaljer

Författare
  • P. V. Chernyshov
  • L. Tomas-Aragones
  • L. Manolache
  • A. Svensson
  • S. E. Marron
  • A. W.M. Evers
  • V. Bettoli
  • G. B. Jemec
  • J. C. Szepietowski
Externa organisationer
  • National Medical University
  • University of Zaragoza
  • Skåne University Hospital
  • Leiden University
  • University of Ferrara
  • Wrocław Medical University
  • Dali Medical
  • Hospital Royo Villanova
  • Aragon Health Sciences Institute
  • Zealand University Hospital
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Dermatologi och venereologi
Originalspråkengelska
Sidor (från-till)1410-1419
Antal sidor10
TidskriftJournal of the European Academy of Dermatology and Venereology
Volym32
Utgåva nummer9
StatusPublished - 2018 maj 5
PublikationskategoriForskning
Peer review utfördJa
Externt publiceradJa