Working memory training decreases hippocampal neurogenesis.

TY - JOUR

T1 - Working memory training decreases hippocampal neurogenesis.

AU - Mohapel, Paul

AU - Orre, Karin

AU - Brundin, Patrik

AU - Frielingsdorf, Helena

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neuronal Survival (013212041), Molecular Psychiatry Unit (013024100), Wallenberg Neuroscience Centre, Lund (0131000110)

PY - 2006

Y1 - 2006

N2 - The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 days. Four days of maze training did not impact neurogenesis regardless of whether reference or working memory paradigms were used. Interestingly, 2 weeks of working memory training using a hidden platform resulted in fewer newborn hippocampal neurons compared with controls that received either cue training or no maze exposure. Stress is a well-established negative regulator of hippocampal neurogenesis. We found that maze training in general, and a working memory task in particular, increased levels of circulating corticosterone after 4 days of training. Our study indicates that working memory training over a prolonged period of time reduces neurogenesis, and this reduction may partially be mediated by increased stress.

AB - The relationship between adult hippocampal neurogenesis and cognition appears more complex than suggested by early reports. We aimed to determine if the duration and task demands of spatial memory training differentially affect hippocampal neurogenesis. Adult male rats were trained in the Morris water maze in a reference memory task for 4 days, or alternatively working memory for either 4 or 14 days. Four days of maze training did not impact neurogenesis regardless of whether reference or working memory paradigms were used. Interestingly, 2 weeks of working memory training using a hidden platform resulted in fewer newborn hippocampal neurons compared with controls that received either cue training or no maze exposure. Stress is a well-established negative regulator of hippocampal neurogenesis. We found that maze training in general, and a working memory task in particular, increased levels of circulating corticosterone after 4 days of training. Our study indicates that working memory training over a prolonged period of time reduces neurogenesis, and this reduction may partially be mediated by increased stress.

KW - corticosterone

KW - reference memory

KW - BrdU

KW - Morris water maze

KW - working memory

U2 - 10.1016/j.neuroscience.2006.07.033

DO - 10.1016/j.neuroscience.2006.07.033

M3 - Article

C2 - 16962715

VL - 142

SP - 609

EP - 613

JO - Neuroscience

JF - Neuroscience

SN - 1873-7544

IS - 3

ER -