WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Abstract

The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P) H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role for WrbA and Nqo1.

Detaljer

Författare
  • Jannette Carey
  • Jiri Brynda
  • Julie Wolfova
  • Rita Grandori
  • Tobias Gustavsson
  • Ruediger Ettrich
  • Ivana Kuta Smatanova
Enheter & grupper
Forskningsområden

Ämnesklassifikation (UKÄ) – OBLIGATORISK

  • Biologiska vetenskaper

Nyckelord

Originalspråkengelska
Sidor (från-till)2301-2305
TidskriftProtein Science
Volym16
Utgåva nummer10
StatusPublished - 2007
PublikationskategoriForskning
Peer review utfördJa