WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases

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WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases. / Carey, Jannette; Brynda, Jiri; Wolfova, Julie; Grandori, Rita; Gustavsson, Tobias; Ettrich, Ruediger; Smatanova, Ivana Kuta.

I: Protein Science, Vol. 16, Nr. 10, 2007, s. 2301-2305.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

Harvard

Carey, J, Brynda, J, Wolfova, J, Grandori, R, Gustavsson, T, Ettrich, R & Smatanova, IK 2007, 'WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases', Protein Science, vol. 16, nr. 10, s. 2301-2305. https://doi.org/10.1110/ps.073018907

APA

Carey, J., Brynda, J., Wolfova, J., Grandori, R., Gustavsson, T., Ettrich, R., & Smatanova, I. K. (2007). WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases. Protein Science, 16(10), 2301-2305. https://doi.org/10.1110/ps.073018907

CBE

Carey J, Brynda J, Wolfova J, Grandori R, Gustavsson T, Ettrich R, Smatanova IK. 2007. WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases. Protein Science. 16(10):2301-2305. https://doi.org/10.1110/ps.073018907

MLA

Vancouver

Carey J, Brynda J, Wolfova J, Grandori R, Gustavsson T, Ettrich R et al. WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases. Protein Science. 2007;16(10):2301-2305. https://doi.org/10.1110/ps.073018907

Author

Carey, Jannette ; Brynda, Jiri ; Wolfova, Julie ; Grandori, Rita ; Gustavsson, Tobias ; Ettrich, Ruediger ; Smatanova, Ivana Kuta. / WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases. I: Protein Science. 2007 ; Vol. 16, Nr. 10. s. 2301-2305.

RIS

TY - JOUR

T1 - WrbA bridges bacterial flavodoxins and eukaryotic NAD(P)H: quinone oxidoreductases

AU - Carey, Jannette

AU - Brynda, Jiri

AU - Wolfova, Julie

AU - Grandori, Rita

AU - Gustavsson, Tobias

AU - Ettrich, Ruediger

AU - Smatanova, Ivana Kuta

PY - 2007

Y1 - 2007

N2 - The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P) H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role for WrbA and Nqo1.

AB - The crystal structure of the flavodoxin-like protein WrbA with oxidized FMN bound reveals a close relationship to mammalian NAD(P) H:quinone oxidoreductase, Nqo1. Structural comparison of WrbA, flavodoxin, and Nqo1 indicates how the twisted open-sheet fold of flavodoxins is elaborated to form multimers that extend catalytic function from one-electron transfer between protein partners using FMN to two-electron reduction of xenobiotics using FAD. The structure suggests a novel physiological role for WrbA and Nqo1.

KW - vitamin K

KW - menaquinone

KW - peripheral membrane proteins

KW - soluble quinones

KW - membrane quinones

KW - chemotherapeutics

KW - shikimate

U2 - 10.1110/ps.073018907

DO - 10.1110/ps.073018907

M3 - Article

VL - 16

SP - 2301

EP - 2305

JO - Protein Science

JF - Protein Science

SN - 1469-896X

IS - 10

ER -