X-ray phase-contrast tomography with a compact laser-driven synchrotron source.

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X-ray phase-contrast tomography with a compact laser-driven synchrotron source. / Eggl, Elena; Schleede, Simone; Bech, Martin; Achterhold, Klaus; Loewen, Roderick; Ruth, Ronald D; Pfeiffer, Franz.

I: Proceedings of the National Academy of Sciences, Vol. 112, Nr. 18, 2015, s. 5567-5572.

Forskningsoutput: TidskriftsbidragArtikel i vetenskaplig tidskrift

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Eggl, Elena ; Schleede, Simone ; Bech, Martin ; Achterhold, Klaus ; Loewen, Roderick ; Ruth, Ronald D ; Pfeiffer, Franz. / X-ray phase-contrast tomography with a compact laser-driven synchrotron source. I: Proceedings of the National Academy of Sciences. 2015 ; Vol. 112, Nr. 18. s. 5567-5572.

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TY - JOUR

T1 - X-ray phase-contrast tomography with a compact laser-driven synchrotron source.

AU - Eggl, Elena

AU - Schleede, Simone

AU - Bech, Martin

AU - Achterhold, Klaus

AU - Loewen, Roderick

AU - Ruth, Ronald D

AU - Pfeiffer, Franz

PY - 2015

Y1 - 2015

N2 - Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a CLS well-suited for applications of more advanced--and more challenging--X-ray imaging approaches, such as X-ray multimodal tomography. Here we present, to our knowledge, the first results of a first successful demonstration experiment in which a monochromatic X-ray beam from a CLS was used for multimodal, i.e., phase-, dark-field, and attenuation-contrast, X-ray tomography. We show results from a fluid phantom with different liquids and a biomedical application example in the form of a multimodal CT scan of a small animal (mouse, ex vivo). The results highlight particularly that quantitative multimodal CT has become feasible with laser-driven CLS, and that the results outperform more conventional approaches.

AB - Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron light sources (CLS), which use an infrared (IR) laser cavity in combination with a small electron storage ring. Hard X-rays are produced through the process of inverse Compton scattering upon the intersection of the electron bunch with the focused laser beam. The produced X-ray beam is intrinsically monochromatic and highly collimated. This makes a CLS well-suited for applications of more advanced--and more challenging--X-ray imaging approaches, such as X-ray multimodal tomography. Here we present, to our knowledge, the first results of a first successful demonstration experiment in which a monochromatic X-ray beam from a CLS was used for multimodal, i.e., phase-, dark-field, and attenuation-contrast, X-ray tomography. We show results from a fluid phantom with different liquids and a biomedical application example in the form of a multimodal CT scan of a small animal (mouse, ex vivo). The results highlight particularly that quantitative multimodal CT has become feasible with laser-driven CLS, and that the results outperform more conventional approaches.

U2 - 10.1073/pnas.1500938112

DO - 10.1073/pnas.1500938112

M3 - Article

VL - 112

SP - 5567

EP - 5572

JO - Proceedings of the National Academy of Sciences

T2 - Proceedings of the National Academy of Sciences

JF - Proceedings of the National Academy of Sciences

SN - 1091-6490

IS - 18

ER -